Electrophysiological and Regional Cerebral Blood Flow Changes Associated with Direct Infusion Edema
Studies of brain edema using the direct infusion model have shown that regional white matter CBF (rCBFw) remains constant with saline infusion (Marmarou et al. 1980), yet is reduced with serum infusion (Tanaka et al. 1981), suggesting the influence of a blood factor. It still remains unclear whether the reduction in rCBFw due to this type of vasogenic edema causes any direct impairment of regional gray matter CBF (rCBFg) and cerebral function at the stage when the rise in ICP is still minimum. In the present study, we used a similar edema model to study the effect of white matter infusion edema upon rCBFg and the degree to which electrophysiological function is altered under these conditions.
KeywordsCatheter Ischemia Neurol Pentobarbital Gallamine
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