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Konservative Therapie des chronischen Ulkusleidens — Indikation und Medikamentenwahl für die Langzeittherapie (Rezidivprophylaxe)

  • R. Gugler
Conference paper
Part of the Interdisziplinäre Gastroenterologie book series (GASTROENTEROLOG)

Zusammenfassung

Eine Abwägung von Nutzen und Risiko einer Langzeitthreapie ist nur möglich, wenn Kenntnisse über den natürlichen Verlauf einer Erkrankung vorhanden sind; solche exakten Daten sind für die Ulkuskrankheit trotz ihrer Häufigkeit und der kaum noch zu überblickenden Zahl an therapeutischen Untersuchungen bis heute gering. Charakteristisch sind für die Ulkuskrankheit 1) die grundsätzlich benigne Natur der Erkrankung, 2) eine hohe Neigung zur Spontanheilung, die jedoch geographisch bedingte Unterschiede mit einer Variation zwischen 30 und 80% aufweist [13, 17, 26], 3) eine hohe Neigung zum Rezidiv.

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Literatur

  1. 1.
    Bardhan KD (1980) Intermittent treatment of duodenal ulcer with Cimetidine. Br Med J 281:20–22PubMedCrossRefGoogle Scholar
  2. 2.
    Bardhan KD (1981) Long-term management of duodenal ulcer — a physician’s view. In: Baron JH (ed) Cimetidine in the eighties. Livingstone, Edinburgh, pp 95–112Google Scholar
  3. 3.
    Bardhan KD, Cole DS, Hawkins BW, Franks CR (1982) Does treatment with Cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Br Med J 284:621–623CrossRefGoogle Scholar
  4. 4.
    Bodemar G, Walan A (1978) Maintenance treatment of recurrent peptic ulcer by Cimetidine. Lancet 1:403–407PubMedCrossRefGoogle Scholar
  5. 5.
    Bodemar G, Walan A (1980) Two-year-follow-up after one year’s treatment with Cimetidine or placebo. Lancet 1:38–39PubMedCrossRefGoogle Scholar
  6. 6.
    Bodemar G, Gotthard R, Ström M, Walan A (1981) Maintenance treatment — length of therapy and indications. In: Baron JH (ed) Cimetidine in the eighties. Livingstone, Edinburgh, pp 75–84Google Scholar
  7. 7.
    Boyd EJS, Wilson JA, Wormsley KG (1982) Review of the use of ranitidine in the prevention of ulcer recurrence (Abstracts). The ranitidine Symposium. World Congr Gastroenterology, p 8Google Scholar
  8. 8.
    Burland WL, Hawkins BW, Horton RJ, Beresford J (1978) The longer treatment of duodenal ulcer with Cimetidine. In: Wastell C, Lance P (eds) Cimetidine. The Westminster Hospital Symposium. Linvingstone, Edinburgh, pp 66–78Google Scholar
  9. 9.
    Burland WL, Hawkins BW, Beresford J (1980) Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study. Postgrad Med J 56:173–176PubMedCrossRefGoogle Scholar
  10. 10.
    Cockel R (1981) Ranitidine in the long term treatment of gastric ulcers. In: The clinical use of ranitidine. Barbican Conference Centre Abstracts, p 19Google Scholar
  11. 11.
    Danielsson A, Ek B, Steen L (1981) Effect of fifteen months of double-blind treatment with Cimetidine and placebo on peptic ulcer recurrence. Eur J Clin Pharmacol 19:335–341PubMedCrossRefGoogle Scholar
  12. 12.
    Dölle W (1980) Histamine-H2-receptor antagonists in short and long term treatment of gastric ulcer. In: Holtermüller KH, Malagelada JR (eds) Advances in ulcer disease. Excerpta Medica, Amsterdam, pp 330–335Google Scholar
  13. 13.
    Doll R, Hill ID, Hutton C, Underwood DJ (1962) Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet 11:793–796CrossRefGoogle Scholar
  14. 14.
    Eichenberger PM, Giger M, Mattle W (1982) Behandlung und Rezidivprophylaxe des Ulcus duodeni mit Pirenzepin und Cimetidin. Schweiz Med Wochenschr 112:25–30PubMedGoogle Scholar
  15. 15.
    Galeone M, Moise G, Casula PL, Bignamini AA (1982) Eine zweijährige Studie zum Auftreten von Ulkusrezidiven nach Proglumid-Therape. Med Welt 32:173–175Google Scholar
  16. 16.
    Gudmand-Hoyer E, Birger-Jensen K, Krag E, Rask-Madsen J, Rahbek I, Rune J, Wulff HR (1978) Prophylactic effect of Cimetidine in duodenal ulcer disease. Br Med J 1:1095–1097PubMedCrossRefGoogle Scholar
  17. 17.
    Holtermüller KH (1978) Natürlicher Verlauf der Ulkuskrankheit. In: Blum AL, Siewert JR (Hrsg) Ulcustherapie. Springer, Berlin Heidelberg New York, S 63–70Google Scholar
  18. 18.
    Machel RJ, Ciclitiva PJ, Farthing MJG (1978) Cimetidine in the prevention of gastric ulcer relapse. Postgrd Med J 55:393CrossRefGoogle Scholar
  19. 19.
    Machel RJ, Ciclitiva PJ, Farthing MJG, Dick AP, Hunter JO (1979) The prevention of gastric ulcer relapse with Cimetidine. Gastroenterology 76:1091Google Scholar
  20. 20.
    Marks IN, Lucke W, Wright JP, Girdwood AH (1981) Ulcer healing and relapse rates after initial treatment with Cimetidine or sucralfate. J Clin Gastroenterol 3:163–165PubMedGoogle Scholar
  21. 21.
    Martin DF, Hollanders D, May SJ, Ravenscroft MM, Tweedle DEF, Miller JP (1981) Difference in relapse rates of duodenal ulcer after healing with Cimetidine or tripotas-sium dicitrate bismuthate. Lancet 1:7–10PubMedCrossRefGoogle Scholar
  22. 22.
    McMillen MAD, Ambis D, Siegel JH (1978) Cimetidine and mental confusion. N Engl J Med 298:284PubMedGoogle Scholar
  23. 23.
    Mekel RCPM (1978) Long term treatment with Cimetidine. S Afr Med J 54:1089PubMedGoogle Scholar
  24. 24.
    Mekel RCPM (1980) Two year maintenance treatment with Cimetidine for duodenal ulcers. S Afr Med J 57:293Google Scholar
  25. 25.
    Pounder RE (1981) Model for medical treatment for duodenal ulcer. Lancet 1:29–30PubMedCrossRefGoogle Scholar
  26. 26.
    Rune S J, Mollman KM, Rahbeck J (1980) Frequency of relapses in duodenal ulcer patients treated with Cimetidine during symptomatic periods. Scand J Gastroenterol [Suppl] 15:85–92Google Scholar
  27. 27.
    Scheurer U, Witzel L, Halter F, Keller HM , Huber R, Galeazzi R (1977) Gastric and duodenal ulcer healing and placebo treatment. Gastroenterology 72:838–841PubMedGoogle Scholar
  28. 28.
    Somogyi A, Gugler R (1982) Drug interactions with Cimetidine. Clin Pharmacokinet 7:23–41PubMedCrossRefGoogle Scholar
  29. 29.
    Tomasetti P, Stangheilini E, Bonora G, Vezzadini A, Labo G (1981) Comparative trial on healing and relapse of duodenal ulcer treated with trithiozine or Cimetidine. Curr Ther Res 29:517–524Google Scholar
  30. 30.
    Wulff HR, Rune SJ (1978) A comparison of studies on the treatment of gastric ulceration with Cimetidine. In: Wastell C, Lance P(eds) Cimetidine. Livingstone, Edinburgh London New York, pp 281–288Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • R. Gugler

There are no affiliations available

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