Abstract
During preclinical studies on new radiological contrast media the potential effect on reproductive performance and fertility must be evaluated. Two conventional oral cholecystographic agents, iopanoic acid and iopronic acid, were administered to rats through the periods of gametogenesis, mating, gestation, parturition and lactation. They produced a dose related weight loss in both males and females. All males proved fertile; in the females a selective maternally orientated effect of the two compounds on the process of gestation was assessed (Tables 1 and 2).
Iopamidol, a new low osmolality compound was also studied and it did not show any adverse effects on fertility and reproductive performance (Table 3).
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© 1984 Springer-Verlag
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Tirone, P., Boldrini, E. (1984). The Effects of Radiological Contrast Media on the Reproduction System of the Rat. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_79
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DOI: https://doi.org/10.1007/978-3-642-69132-4_79
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12452-8
Online ISBN: 978-3-642-69132-4
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