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In Vitro Cytotoxicity of Nickel Chloride on a Human Pulmonary Epithelial Cell Line (A 549)

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Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 7))

Abstract

The results of an in vitro study of the dose-effect response with nickel chloride on human epithelial cell line A 549 are reported. NiCl2 in amounts ranging from 0 to 10-3 M, produced a decrease in cell growth rate, a diminished content of cell ATP, and a loss of viability at the highest concentration. No characteristic ultrastructural changes were seen on TEM preparations.

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Author information

Authors and Affiliations

  1. U.122 INSERM, Laboratoire de Toxicologie, Centre Pharmaceutique de l’Université Paris-Sud, rue J.-B. Clément, 92290, Châtenay-Malabry, France

    A. Dubreuil, G. Bouley & C. Boudene

  2. U.122 INSERM, Laboratoire de Biologie Cellulaire, Centre Pharmaceutique de l’Université Paris-Sud, rue J.-B. Clément, 92290, Châtenay-Malabry, France

    S. Duret & J.-C. Mestre

Authors
  1. A. Dubreuil
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  2. G. Bouley
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  3. S. Duret
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  4. J.-C. Mestre
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  5. C. Boudene
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Department of Pharmacology, Catholic University of the Sacred Heart, Via della Pineta Sacchetti 644, 00168, Rome, Italy

    Paolo Preziosi

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© 1984 Springer-Verlag

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Dubreuil, A., Bouley, G., Duret, S., Mestre, JC., Boudene, C. (1984). In Vitro Cytotoxicity of Nickel Chloride on a Human Pulmonary Epithelial Cell Line (A 549). In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_68

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  • DOI: https://doi.org/10.1007/978-3-642-69132-4_68

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12452-8

  • Online ISBN: 978-3-642-69132-4

  • eBook Packages: Springer Book Archive

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