Indomethacin Induced Intestinal Toxicity is Blocked by Sodium Salicylate at 24 and 48 Hours Post Treatment

Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)


Single 10 mg/kg oral dose of indomethacin induced so-called non-fatal intestinal ulceration. Tensile strength of the intestinal wall gradually decreased at 24, 48, and 72 h after treatment. In animals treated with sodium salicylate 24 and 48 h after administration of indomethacin the tensile strength of the intestinal wall was restored to normal value, the protective effect was related to dose.

Key words

Indomethacin Intestinal ulcer Cytoprotective effect Sodium salicylate 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • E. Ezer
    • 1
  1. 1.Chemical Works of Gedeon Richter, Ltd.Pharmacological Research CentreBudapestHungary

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