The Influence of Paracetamol on the Hepatic Biosynthesis of Lecithin
In paracetamol induced liver injury changes in the phospholipid components of microsomal membranes are usual. Direct incubation of paracetamol with subcellular fractions of human liver specimens did not alter the biosynthesis of lecithin. Preincubation of liver slices with paracetamol led to an increased synthesis of lecithin. The presence of intact cells and the integrity of hepatocellular function seem to be a prerequisite for the poisoning effects in vitro.
Key wordsParacetamol Liver injury Phospholipids
Unable to display preview. Download preview PDF.
- Toghill P, Williams R, Stephens J (1969) Acute hepatic necrosis following an overdose of paracetamol. Gastroenterology 27: 773–776Google Scholar