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The Influence of Paracetamol on the Hepatic Biosynthesis of Lecithin

  • J. Lohmann
  • U. Lessing
  • H. Schriewer
  • M. Clemens
  • U. Gerlach
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)

Abstract

In paracetamol induced liver injury changes in the phospholipid components of microsomal membranes are usual. Direct incubation of paracetamol with subcellular fractions of human liver specimens did not alter the biosynthesis of lecithin. Preincubation of liver slices with paracetamol led to an increased synthesis of lecithin. The presence of intact cells and the integrity of hepatocellular function seem to be a prerequisite for the poisoning effects in vitro.

Key words

Paracetamol Liver injury Phospholipids 

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References

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. Lohmann
    • 1
  • U. Lessing
    • 1
  • H. Schriewer
    • 1
  • M. Clemens
    • 2
  • U. Gerlach
    • 1
  1. 1.Medizinische UniversitätsklinikMünsterFederal Republic of Germany
  2. 2.Chirurgische UniversitätsklinikMünsterFederal Republic of Germany

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