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Active Metabolites in Toxicology: The Role of Cytochrome P-448 and Flavoprotein Oxidases

  • Conference paper
Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 7))

Abstract

The activation of toxic chemicals and carcinogens into reactive intermediates involves oxygenation in hindered positions of the molecule, by cytochrome P-448 (LM4), flavoprotein oxidoreductases, or transoxygenation during prostaglandin biosynthesis. Cytochrome P-450 (LM2) does not oxygenate in hindered positions and therefore generally detoxicates carcinogens and toxic chemicals. Cytochrome P-448 has a different active site from cytochrome P-450, which enables it to oxygenate substrates in conformationally-hindered positions.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Surrey, Guildford, Surrey, GU2 5XH, Great Britain

    D. V. Parke & C. Ioannides

Authors
  1. D. V. Parke
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  2. C. Ioannides
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Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Department of Pharmacology, Catholic University of the Sacred Heart, Via della Pineta Sacchetti 644, 00168, Rome, Italy

    Paolo Preziosi

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© 1984 Springer-Verlag

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Parke, D.V., Ioannides, C. (1984). Active Metabolites in Toxicology: The Role of Cytochrome P-448 and Flavoprotein Oxidases. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_27

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  • DOI: https://doi.org/10.1007/978-3-642-69132-4_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12452-8

  • Online ISBN: 978-3-642-69132-4

  • eBook Packages: Springer Book Archive

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