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Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals pp 159–163Cite as

Testicular Effects of Some Xanthine Derivatives in the Rat

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Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 7))

Abstract

Testicular toxicity as well as effects on body weight gain and food consumption of four xanthine derivatives were studied in the Sprague-Daw-ley rat. The influence on toxicity by variation of the substituent at positions 1 and 3 on the xanthine skeleton was tested. The compounds were administered orally once a day for 1 month. The 1-methylated xanthines seemed to be more toxic than the non-methylated compounds.

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References

  • Dahlbäck M, Karlberg IB, Ryrfeldt Å, Sörenby L, Havu N (1981) General toxicity in rats of D 4122 and D 4026 with special reference to testicular effects — a preliminary study. Data on file at Draco

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Author information

Authors and Affiliations

  1. Research and Development Laboratories, AB Draco, Box 1707, 2201 01, Lund, Sweden

    M. Dahlbäck & Å. Ryrfeldt

Authors
  1. M. Dahlbäck
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  2. Å. Ryrfeldt
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Department of Pharmacology, Catholic University of the Sacred Heart, Via della Pineta Sacchetti 644, 00168, Rome, Italy

    Paolo Preziosi

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© 1984 Springer-Verlag

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Dahlbäck, M., Ryrfeldt, Å. (1984). Testicular Effects of Some Xanthine Derivatives in the Rat. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_21

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  • DOI: https://doi.org/10.1007/978-3-642-69132-4_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12452-8

  • Online ISBN: 978-3-642-69132-4

  • eBook Packages: Springer Book Archive

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