Role of Calcium and Cyclic Nucleotides in the Regulation of Intestinal Ion Transport
Studies in mammalian intestine reveal that a variety of humoral, microbial and pharmacological agents known to alter ion transport (either in the absorptive or secretory direction) appear to do so by altering the intracellular concentrations of calcium, cyclic AMP, or cyclic GMP (Field 1981). An increase in the intracellular concentration of any one of these mediators results in net secretion, whereas a decrease results in net absorption. Mammalian ileum can both absorb and secrete water and electrolytes. Net secretion can result from inhibition of an active absorptive process and/or the stimulation of an active secretory process. In contrast, the intestine of the marine teleost, Pseudopleuronectes americanus (winter flounder), only absorbs. This intestine is also devoid of crypts, which are believed to be the site of fluid secretion in mammalian intestine.
KeywordsCyclic Nucleotide Intracellular Mediator Transepithelial Potential Difference Rabbit Ileum Mammalian Intestine
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