Neurochemical and Model Membrane Studies in Demyelinating Diseases

  • B. Maggio
  • F. A. Cumar
  • G. A. Roth
  • C. G. Monferrán
  • G. D. Fidelio
Part of the Acta Neuropathologica Supplementum book series (NEUROPATHOLOGIC, volume 9)


One of the main roles of myelin in the central nervous system seems to be related to maintaining a low ionic conductivity around axons (1) and a modification of its composition, intermodular interactions and concomitant permeability changes can be particularly perturbing and lead to several disorders that involve “demyelination”. This word simply means “myelin loss” in general and occurs to a limited extent in some processes and very dramatically in others, the alteration has been well documented from the morphological point of view and with regard to the ultrastructural sequences of myelin damage (2–4). However, from the point of view of membrane biophysics the concept of demyelination becomes much less defined since the bulk of experimental evidence in the biomembrane field has shown that membrane structures completely different in their chemical composition, metabolism or permeability, are nevertheless indistinguishable from their ultrastructural morphology.


Experimental Autoimmune Encephalomyelitis Myelin Basic Protein Experimental Allergic Encephalomyelitis Myelin Membrane Lipid Alteration 
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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • B. Maggio
    • 1
  • F. A. Cumar
    • 1
  • G. A. Roth
    • 1
  • C. G. Monferrán
    • 1
  • G. D. Fidelio
    • 1
  1. 1.Departamento de Química Biológica, Facultad de Ciencias QuímicasCiudad UniversitariaCórdobaArgentina

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