Abstract
The vessel wall, the vessel content and its flow behaviour form a, highly complex regulative circuit, which is until now understood only in a few of its manifold interactions. The flow forces and the flow patterns for example are able to affect the formed blood elements as well as the vessel wall. The geometry and the biochemical metabolism of the vessel wall will in turn influence blood flow and properties of blood cells. All components that interact may be considered to be involved in atherogenesis. Amongst the formed elements of the blood, the platelets are suspected to play a paramount role in the development of arterial thrombosis and the early stages of arteriosclerosis.
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Supported in parts by Fritz Thyssen Foundation, Cologne
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References
Antonini G, Guiffant G, Quemada D, Dosne AM (1978) Estimation of platelet diffusivity in flowing blood. Biorheology 15: 111–117
Baldauf W, Wurzinger LJ, Kinder J (1978) The role of stagnation point flow in the formation of platelet thrombi on glass surfaces in tubes with various geometry. Path Res Pract 163: 9–33
Begent N, Born GVR (1970) Growth rate in vivo of platelet thrombi, produced by iontophoresis of ADP, as a function of mean blood flow velocity. Nature 227: 926–930
Bennet L (1968) Blood flow: velocity profile continuity near a wall. Biorheology 5: 253–262
Bergqvist D, Arfors KE (1977) The role of red cells in haemostatic plug formation in the isolated rabbit mesentery. Thromb Res 11: 95–100
Feuerstein IA, Brophy JM, Brash JL (1975) Platelet transport and adhesion to reconstituted collagen and artificial surfaces. Trans Am Soc Artif Intern Organs 21: 427–434
Fischer TM, Schmid-Schönbein H (1977) Tank tread motion of red cell membranes in viscometric flow: behaviour of intracellular and extracellular markers (with film). Blood Cells 3: 351–365
Fischer TM, Stöhr-Liesen M, Schmid-Schönbein H (1978) Red cells as a fluid droplet; tank tread like motion of human erythrocyte membrane in shear flow. Science 202: 894–896
Forstrom RJ, Bartelt K, Blackshear PL, Wood T (1975) Formed element deposition onto filtering walls. Trans Am Soc Artif Intern Organs 21: 602–607
Goldsmith HL, Yu SSK, Marlow J (1975) Fluid mechanical stress and the platelet. Thromb Diathes Haemorrh 34: 32–41
Keller KH (1981) The dynamics of the interaction of cells with surfaces. In: Salzman EW (ed) Interaction of the blood with natural and artificial surfaces. Marcel Dekker, New York Basel, p 119
Kinder J, Kratzer M (1975) Geschwindigkeitsmessung im Inneren komplizierter Strömungen mit einem Lichtschnittverfahren. Biomed Technik 20: 11–12
Leonard EF (1972) The role of flow in thrombogenesis. Bull NY Acad Med 48: 273–280
Marzec U, Johnston GG, Bernstein EF (1975) Platelet function in calves: a study of adhesion, aggregation, release, clotting factor activity and life span. Trans Am Soc Artif Intern Organs 21: 581–585
Müller-Mohnssen H (1971) Pathogenese der Koronarsklerose und Strömungsmechanik. Münchner Med Wschr 113: 604–616
Richardson PD (1973) Effect of blood flow velocity on growth rate of platelet thrombi. Nature 245: 103–104
Schmid-Schönbein GW, Skalak R, Usami S, Chien S (1980) Cell distribution in capillary networks. Microvasc Res 19: 18–44
Schmid-Schönbein H, Born GVR, Richardson PD, Cusack N, Rieger H, Forst R, Rohling-Winkel I, Blasberg P, Wehmeyer A (1981) Rheology of thrombotic processes in flow: the interaction of erythrocytes and thrombocytes subjected to high flow forces. Biorheology 18: 415–444
Stewart GJ, Ritchie GM, Lynch PR (1974) Venous endothelial damage produced by massive sticking and emigration of leukocytes. Am J Path 74: 507
Turitto VT, Baumgartner HR (1974) Effects of physical factors on platelet adherence to subendothelium. Thromb Diathes Haemorrh [Suppl] 60: 17
Turitto VT, Baumgartner HR (1979) Platelet interaction with subendothelium in flowing blood: effect of blood shear rate. Microvasc Res 17: 38–54
Wolf MK, Aronson SB (1961) Growth, fluorescence and metachromasy of cells cultured in the presence of acridin orange. J Histochem Cytochem 9: 22–29
Wurzinger LJ (1979) Hydrodynamisch induzierte Plättchenablagerungen an Glasmqdellen verzweigter, gekrümmter und verengter Gefäßabschnitte und Speziesunterschiede im Plättchenaggregationsverhalten von Mensch, Rind, Schwein, Schaf, Hund, Kaninchen und Truthahn. Dissertation RWTH Aachen
Zucker MB, Vroman L (1969) Platelet adhesion induced by fibrinogen adsorbed onto glass. Proc Soc Exp Biol Med 131: 318
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Blasberg, P., Wurzinger, L.J., Schmid-Schönbein, H. (1983). Microrheology of Thrombocyte Deposition: Effect of Stimulation, Flow Direction, and Red Cells. In: Schettler, G., Nerem, R.M., Schmid-Schönbein, H., Mörl, H., Diehm, C. (eds) Fluid Dynamics as a Localizing Factor for Atherosclerosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69085-3_13
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DOI: https://doi.org/10.1007/978-3-642-69085-3_13
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