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Novel Control Mechanisms of Aldosterone Secretion

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Mineralocorticoids and Hypertension

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

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Abstract

The factors normally thought to be responsible for controlling aldosterone secretion are angiotensin II (A II), potassium, adrenocorticotrophic hormone (ACTH), and sodium. There is, however, good evidence that there are almost certainly other modulators [12]. Contenders for this role include angiotensin III, α-melanocyte-stimulating hormone (MSH), β-lipotropin, N-terminal pro-opiocortin (N-POC), serotonin, 5-methoxytryptamine, dopamine, somatostatin, histamine, prostaglandins, growth hormone, and an as yet unidentified glycopeptide aldosterone-stimulating factor. The purpose of this paper is to review some recent advances in this area.

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References

  1. Aguilera G, Menard R, Catt KJ (1980) Regulatory actions of angiotensin II on receptors and steroidogenic enzymes in adrenal glomerulosa cells. Endocrinology 107: 55–60

    Article  PubMed  CAS  Google Scholar 

  2. Aguilera G, Harwood JP, Catt KJ (1981) Somatostatin modulates effects of angiotensin II in adrenal glomerulosa zone. Nature 292: 262–263

    Article  PubMed  CAS  Google Scholar 

  3. Aikawa T, Hirose T, Matsumoto I. Suzuki T (1979) Secretion of aldosterone in response to histamine in hypophysectomized-nephrectomized dogs. J Endocrinol 81: 325–330

    Article  PubMed  CAS  Google Scholar 

  4. Al-Dujaili EAS, Boscaro M, Espiner EA, Edwards CRW (1980) In vitro and in vivo effects of indoleamines on aldosterone biosynthesis in the rat. Proceedings of VI International Congress of Endocrinology, Melbourne, p 409

    Google Scholar 

  5. Al-Dujaili EAS, Hope J, Estivariz FE, Lowry PJ, Edwards CRW (1981) A naturally circulating human pituitary pro-gamma melanotropin potentiates the adrenal response to ACTH. Nature 291: 156–159

    Article  PubMed  CAS  Google Scholar 

  6. Al-Dujaili EAS, Williams BC, Edwards CRW, Salacinski P, Lowry PJ (1982a) Human γ-melanotropin precursor potentiates cortieotropin-induced adrenal steroidogenesis by stimulating mRNA synthesis. Biochem J 204: 301–305

    PubMed  CAS  Google Scholar 

  7. Al-Dujaili EAS, Boscaro M, Edwards CRW (1982b) An in vitro stimulatory effect of indoleamines on aldosterone biosynthesis in the rat. J Steroid Biochem 17: 351–355

    Article  CAS  Google Scholar 

  8. Boscaro M, Al-Dujaili EAS, Edwards CRW (1979) In vitro studies on the mechanism of inhibition by bromocriptine, lisuride and metergoline of angiotensin II-induced aldosterone release. Acta Endocrinol [Suppl] (Copenh) 225:342

    Google Scholar 

  9. Campbell DJ, Mendelsohn FAO, Adam WR, Funder JW (1981) Is aldosterone secretion under dopaminergic control? Circ Res 49: 1217–1227

    PubMed  CAS  Google Scholar 

  10. Carey RM, Vaughan D, Peach MJ, Ayers C (1978) Activity of (Des-Aspartyl1)-Angiotensin II and Angiotensin II in man. J Clin Invest 61: 20–31

    Article  PubMed  CAS  Google Scholar 

  11. Carey RM, Thorner MO, Ortt EM (1979) Effect of metoclopramide and bromocriptine on the renin-angiotensin-aldosterone system in man. J Clin Invest 63: 727–735

    Article  PubMed  CAS  Google Scholar 

  12. Coghlan JP, Blair-West JR, Denton DA, Fei DT, Fernley RT, Hardy KJ, McDougall JG, Puy R, Robinson PM, Scoggins BA, Wright RD (1979) Control of aldosterone secretion. J Endocrinol 81: 55P–67 P

    PubMed  CAS  Google Scholar 

  13. Costa G, Frisina N, de Pasquale R (1980) Increased aldosterone secretion induced by sulpirde. Clin Endocrinol 13: 1–7

    Article  CAS  Google Scholar 

  14. Duchen LW (1962) The effects of ingestion of hypertonic saline on the pituitary gland in the rat: a morphological study of the pars intermedia and posterior lobe. J Endocrinol 25: 161–168

    Article  CAS  Google Scholar 

  15. Edwards CRW, Thorner MO, Miall PA, Al-Dujaili EAS, Hanker JP, Besser GM (1975) Inhibition of the plasma aldosterone response to frusemide by bromocriptine. Lancet 2: 903–905

    Article  PubMed  CAS  Google Scholar 

  16. Edwards CRW, Al-Dujaili EAS, Boscaro M, Quyyumi S, Miall PA, Rees LH (1980) In vivo and in vitro studies on the effect of metoclopramide on aldosterone secretion. Clin Endocrinol (Oxf) 13:45–50

    Article  CAS  Google Scholar 

  17. Eipper BA, Mains RW (1978) Existence of a common precursor to ACTH and endorphin in the anterior and intermediate lobes of the rat pituitary. J Supramol Struct Cell Biochem 8: 247

    CAS  Google Scholar 

  18. Eipper BA, Mains RE (1980) Structure and biosynthesis of proadrenocorticotropin/endorphin and related peptides. Endocr Rev 1: 1–27

    Article  PubMed  CAS  Google Scholar 

  19. Espiner EA, Lun S (1979) Permissive effect of corticotrophin (ACTH) on aldosterone response to potassium ( K) stimulation in sheep with adrenal transplants. Acta Endocrinol [Suppl] (Copenh) 225: 343

    Google Scholar 

  20. Espiner EA, Al-Dujaili EAS, Martin VI, Edwards CRW (1980) Indoleamines stimulate steroidogenesis in isolated human adrenal cells. Proceedings of VI International Congress of Endocrinology, Melbourne, p 506

    Google Scholar 

  21. Estivariz FE, Hope J, McClean C, Lowry PJ (1980) Purification and characterisation of a gamma-melanotropin precursor from frozen human pituitary glands. Biochem J 191: 125–132

    PubMed  CAS  Google Scholar 

  22. Estivariz FE, Iturriza F, McClean C, Hope J, Lowry PJ (1982) Stimulation of adrenal mitogenesis by N-terminal pro-opiocortin peptides. Nature 297: 419–422

    Article  PubMed  CAS  Google Scholar 

  23. Fang VS, Shian LR (1981) A serotonergic mechanism of the prolactin-stimulating action of metoclopramide. Endocrinology 108: 1622–1627

    Article  PubMed  CAS  Google Scholar 

  24. Gaillard RC, Grossman A. Gillies G, Rees LH, Besser GM (1981) Angiotensin II stimulates the release of ACTH from dispersed rat anterior pituitary cells. Clin Endocrinol (Oxf) 15: 573–578

    Article  CAS  Google Scholar 

  25. Fross MD, Grekin RJ, Gniadek TC, Villareal JZ (1981) Suppression of aldosterone by cyproheptadine in idiopathic aldosteronism. N Engl J Med 305: 181–185

    Article  Google Scholar 

  26. Hauger R, Aguilera G, Catt KJ (1978) Angiotensin II regulates its receptor sites in the adrenal glomerulosa zone. Nature 271: 176–178

    Article  PubMed  CAS  Google Scholar 

  27. Hope J, Ratter SJ, Estivariz FE, McLoughlin L, Lowry PJ (1981) Development of a radioimmunoassay for an amino-terminal peptide of pro-opiocortin containing the γ-MSH region: Measurement and characterization in human plasma. Clin Endocrinol (Oxf) 15: 221–227

    Article  CAS  Google Scholar 

  28. Howe A, Thody AJ (1970) The effect of ingestion of hypertonic saline on the melanocyte-stimulating hormone content and histology of the pars intermedia of the rat pituitary gland. J Endocrinol 46: 201–208

    Article  PubMed  CAS  Google Scholar 

  29. James VHT, Tunbridge RDG, Wilson GS (1976) Studies on the control of aldosterone secretion in man. J Steroid Biochem 7: 941–948

    Article  PubMed  CAS  Google Scholar 

  30. Kobayashi Y, Takena M (1976) A morphometric study on the pars intermedia of the hypophysis during impairment of the renin-angiotensin-aldosterone system in sodium depleted mice. Cell Tissue Res 168: 153–159

    Article  PubMed  CAS  Google Scholar 

  31. Mantero F, Opocher G, Armanini D, Boscaro M, Edwards CRW (1979) Effect of serotonin (5-HT) on plasma aldosterone in man. Acta Endocrinol [Suppl] (Copenh) 255: 345

    Google Scholar 

  32. Maran JW, Yates EF (1977) Cortisol secretion during intrapituitary infusion of angiotensin II in conscious dogs. Am J Physiol 233: 273–285

    Google Scholar 

  33. Mason PA, Fraser R, Semple PF, Morton JJ (1979) The interaction of ACTH and angiotensin II in the control of corticosteroid plasma concentration in man. J Steroid Biochem 10: 235–239

    Article  PubMed  CAS  Google Scholar 

  34. Matsuoka H, Mulrow PJ, Franco-Saenz R, Li CH (1981) Stimulation of aldo-sterone production by ß-melanotropin. Nature 291: 155–156

    Article  PubMed  CAS  Google Scholar 

  35. McKenna TJ, Island DP, Nicholson WE, Liddle GW (1979) Dopamine inhibits angiotensin-stimulated aldosterone biosynthesis in bovine adrenal cells. J Clin Invest 64: 287–291

    Article  PubMed  CAS  Google Scholar 

  36. Nakanishi S, Inove A, Kita T, Nakamura M, Chang ACY, Cohen SN, Numa S (1979) Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipo-tropin precursor. Nature 278: 423

    Article  PubMed  CAS  Google Scholar 

  37. Norbiato G, Bevilacqua M, Raggi U, Micossi P, Moroni C (1977) Metoclopramide increases plasma aldosterone in man. J Clin Endocrinol Metab 45: 1313–1316

    Article  PubMed  CAS  Google Scholar 

  38. Pedersen RC, Brownie AC (1979) Failure of ACTH to mimic the stress-induced activation of rat adrenocortical cholesterol ester hydrolase in vivo. J Steroid Biochem 11: 1393–1400

    Article  PubMed  CAS  Google Scholar 

  39. Pedersen RC, Brownie AC (1980) Adrenocortical response to corticotropin is potentiated by part of the amino-terminal region of pro-corticotropin/endorphin. Proc Natl Acad Sci USA 77: 2239

    Article  PubMed  CAS  Google Scholar 

  40. Pedersen RC, Brownie AC, Ling N (1980) Pro-adrenocorticotropin/endorphin-derived peptides: Co-ordinate action on adrenal steroidogenesis. Science 208: 1044–1045

    Article  PubMed  CAS  Google Scholar 

  41. Pratt JM, Parkinson CA, Garner AC (1981) Dependence of potassium on angiotensin II for stimulation of aldosterone secretion. Endocrinology 110: 187

    Google Scholar 

  42. Ramsay DJ, Keil LC, Sharpe MC, Shinsako J (1978) Angiotensin II infusion increases vasopressin, ACTH and 11-hydroxycorticoid secretion. A, J Physiol 234: 66–71

    Google Scholar 

  43. Rayyis SS, Horton R (1971) Effect of angiotensin II on adrenal and pituitary function in man. J Clin Endocrinol Metab 32: 539–546

    Article  PubMed  CAS  Google Scholar 

  44. Semple PF, Buckingham JC, Mason PA, Fraser R (1979) Suppression of plasma ACTH concentration by angiotensin II infusion in normal humans and in a subject with 17a-hydroxylase defect. Clin Endocrinol (Oxf) 10: 137–144

    Article  CAS  Google Scholar 

  45. Sobel DO (1982) Angiotensin III mediated ACTH release in vitro. Endocrinology 100:p 135

    Google Scholar 

  46. Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213: 1394–1397

    Article  PubMed  CAS  Google Scholar 

  47. Vinson GP, Whitehouse BJ, Dell A, Etienne T, Morris HR (1980) Characterization of an adrenal zona glomerulosa-stimulating component of posterior pituitary extracts as alpha-MSH. Nature 284: 464–467

    Article  PubMed  CAS  Google Scholar 

  48. Yamakado M, Franco-Saenz R, Mulrow PJ (1982) Beta-MSH stimulation of aldosterone production: Effect of low sodium diet and site of action. Endocrinology 110:p 135

    Google Scholar 

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© 1983 Springer-Verlag Berlin Heidelberg

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Edwards, C.R.W., Al-Dujaili, E.A.S., Williams, B.C. (1983). Novel Control Mechanisms of Aldosterone Secretion. In: Kaufmann, W., Wambach, G., Helber, A., Meurer, KA. (eds) Mineralocorticoids and Hypertension. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69081-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-69081-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12391-0

  • Online ISBN: 978-3-642-69081-5

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