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Intracellular Action of Mineralocorticoids: The Role of the Flavin Coenzymes and Riboflavin Analogs in Hypertension

  • Conference paper
Book cover Mineralocorticoids and Hypertension

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

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Summary

We have previously shown that the enhanced biosynthesis of renal flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) from riboflavin may be causally related to the aldosterone-mediated reabsorption of Na+. The simultaneous administration of the riboflavin analogs 7,8-dimethyl-10-formylmethyl isoalloxazine (FMI) and 7,8dimethyl-10-(2′-hydroxyethyl) isoalloxazine (HEI) diminished the conversion of riboflavin to FMN by competitively inhibiting the enzyme flavokinase (EC 2 · 7 · 1 · 26). Both analogs acted as natriuretic agents in the presence of aldosterone in a dose-dependent fashion.

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Authors
  1. D. Trachewsky
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Editors and Affiliations

  1. Medizinische Klinik Köln-Merheim und Poliklinik der Universität, Ostmerheimer Straße 200, 5000, Köln 91, Federal Republic of Germany

    Werner Kaufmann , Gerhard Wambach , Albert Helber  & Karl-August Meurer , ,  & 

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© 1983 Springer-Verlag Berlin Heidelberg

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Trachewsky, D. (1983). Intracellular Action of Mineralocorticoids: The Role of the Flavin Coenzymes and Riboflavin Analogs in Hypertension. In: Kaufmann, W., Wambach, G., Helber, A., Meurer, KA. (eds) Mineralocorticoids and Hypertension. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69081-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-69081-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12391-0

  • Online ISBN: 978-3-642-69081-5

  • eBook Packages: Springer Book Archive

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