Summary
To gain insight into the mechanism of mineralocorticoid-induced hypertension in man, we performed hemodynamic studies on six normotensive volunteers before and during administration of the synthetic steroid 9α-fluorocortisol (0.8 mg daily) for a period of 6 weeks. Within the first week of steroid administration, an increase in mean arterial blood pressure was the consequence of an increased total peripheral resistance. In a further study, performed on seven subjects, plasma noradrenaline concentration and reactivity to exogenous noradrenaline were determined before and during administration of the mineralocorticoid. Plasma noradrenaline concentration decreased and reactivity to exogenous noradrenaline increased during steroid administration.
The mechanism underlying the increase in total peripheral resistance during long- term mineralocorticoid administration remains unclear. Increased sympathetic tone does not seem to be a factor since plasma noradrenaline decreased considerably. Pressor response to noradrenaline increased probably due to decreased sympathetic tone.
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Philipp, T., Lüth, B., Wucherer, G., Distler, A. (1983). Mechanism of Mineralocorticoid-induced Hypertension in Man. In: Kaufmann, W., Wambach, G., Helber, A., Meurer, KA. (eds) Mineralocorticoids and Hypertension. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69081-5_10
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DOI: https://doi.org/10.1007/978-3-642-69081-5_10
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