Abstract
The currently accepted mechanism of action of aldosterone, in common with other steroid hormones, involves an initial step of binding of the hormone to specific, high-affinity cytoplasmic receptors, with subsequent binding of the steroid-receptor complex to the chromatin. This initial step is followed by DNA-directed, RNA-mediated changes in protein synthesis, which constitute or mediate the physiological effect of the steroid [1]. Though the evidence for the necessary involvement of mineralocorticoid receptors in renal electrolyte handling is circumstantial, it is nonetheless strong. There is, for example, an excellent correlation between the dose-response curve for the inhibition of 3 H-aldosterone binding by spironolactone and that for its antagonism of the aldosterone effect on urinary electrolytes [2].
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© 1983 Springer-Verlag Berlin Heidelberg
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Krozowski, Z., Stephenson, G., Quirk, S., Funder, J. (1983). Mineralocorticoid Receptors and Extrinsic Specificity-conferring Mechanisms. In: Kaufmann, W., Wambach, G., Helber, A., Meurer, KA. (eds) Mineralocorticoids and Hypertension. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69081-5_1
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DOI: https://doi.org/10.1007/978-3-642-69081-5_1
Publisher Name: Springer, Berlin, Heidelberg
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