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Intestinale Sekretion bei entzündlichen Darmerkrankungen

  • Conference paper
Entzündliche Erkrankungen des Dickdarms

Part of the book series: Interdisziplinäre Gastroenterologie ((GASTROENTEROLOG))

Zusammenfassung

Bei üblichen Ernährungsgewohnheiten gelangen beim Gesunden pro 24 h ca. 1500-2000 ml einer plasmaisotonen elektrolythaltigen Flüssigkeit in das Colon, die in Abhängigkeit von Art und Menge der Nahrung unterschiedlich zusammengesetzt ist. Dominierendes Ion ist in allen Fällen Na+ (> 120 mmol/1) [14]. Entlang dem ca. 150 cm langen Colon wird die Flüssigkeitsmenge bis auf ca. 100 ml, die mit dem Stuhl ausgeschieden wird, absorbiert. Entscheidenden Anteil an der passiven Wasserabsorption hat dabei die aktive und sehr effiziente Natriumabsorption, gefolgt von einer ebenso effizienten Chloridabsorption, so daß mit dem Stuhl unter physiologischen Bedingungen nur vergleichsweise geringe IVLengen von Elektrolyten und Wasser verlorengehen [6, 51, 73, 74]. Die Colonschleimhaut besitzt darüber hinaus noch eine um den Faktor 3 höhere Funktionsreserve, so daß bei kontinuierlichem Elektrolyt- und Flüssig- keitseinstrom an der Ileocöcalklappe unter optimalen Bedingungen etwa 61 H2O und mehr als 800 mmol Na+ absorbiert werden können [14]. Für klinische Folgezustände bei Schleimhauterkrankungen oder nach resezierenden Operationen am Colon ist von Bedeutung, daß die absorptive Kapazität in den proximalen Colonabschnitten am größten ist und nach distal abnimmt [16, 47], wobei die Effizienz der Absorption selbst aufgrund struktureller Eigenschaften der Dickdarmschleimhaut analwärts zunimmt.

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Authors
  1. R. Wanitschke
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  2. K. J. Goerg
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Editors and Affiliations

  1. I. Medizinische Abteilung, Städtischen Krankenhauses München-Neuperlach, Oskar-Maria-Graf-Ring 51, München 83, D-8000, Deutschland

    Rudolf Ottenjann

  2. Gastroenterologische Abteilung, Dept. für Innere Medizin der Universität, Kantonsspital, Basel, CH-4031, Switzerland

    Hansjürg Fahrländer

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© 1983 Springer-Verlag Berlin Heidelberg

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Wanitschke, R., Goerg, K.J. (1983). Intestinale Sekretion bei entzündlichen Darmerkrankungen. In: Ottenjann, R., Fahrländer, H. (eds) Entzündliche Erkrankungen des Dickdarms. Interdisziplinäre Gastroenterologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69062-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-69062-4_2

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  • Print ISBN: 978-3-642-69063-1

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