Glucagon II pp 611-643 | Cite as

Spasmolytic Action and Clinical Use of Glucagon

  • B. Diamant
  • J. Picazo
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 66 / 2)


The inhibitory effect of glucagon on the motility of the gastrointestinal tract was first described by Stunkard et al. (1955) who noted inhibition of gastric hunger contractions in humans. The mechanism behind this effect could not be determined, but it was noted that it could be “independent of its effect on carbohydrate metabolism” since intravenous glucose injections failed to mimic the effect. Glucagon has since been found to have inhibitory action on the smooth muscle of many organs and species. Wingate and Pearce (1979) have compiled an extensive list of pertinent investigations focusing on the effects of glucagon on gastrointestinal motility, secretion, and absorption, and on blood flow (Table 1). Table 2 lists investigations in other areas in which glucagon has been found to have a similar smooth muscle relaxing effect.


Lower Esophageal Sphincter Hyoscine Butylbromide Spasmolytic Action Nonocclusive Mesenteric Ischemia Ureteral Colic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • B. Diamant
  • J. Picazo

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