Causal Histogenesis (Pauwels, Kummer) and Related Biomechanical Discoveries as a Basis for the Cementless Fixation of Hip Endoprostheses

Abstract

The structural makeup of an organ is a product of functional adaptation. An implant that is inserted to replace a skeletal defect must conform to the prevailing scheme. In this way disruptive effects can be avoided, and, because the implant is surrounded by living and thus reactive tissue, proprioceptive stimuli can be preserved. These are necessary as control signals, especially for the cell and its dependent functions, because metabolic feedback is crucial in ensuring that tissues develop and are maintained in accordance with the functions they perform. The “master program” is the genetic code. The functional stimuli associated with static and dynamic loads provide a kind of trigger impulse of varying magnitude and quality which initiates processes, either directly or indirectly, that carry out the adaptation to loads within genetic constraints.