Neothramycin

  • N. Tanaka
Part of the Antibiotics book series (ANTIBIOTICS, volume 6)

Abstract

Neothramycin has been isolated from Streptomyces MC916-C4 in the laboratory of Dr. Hamao Umezawa(Takeuchi et al., 1976). It is a potent antitumor antibiotic of the pyrrolo(l,4)benzodiazepine group, which anthramycin (cf. a review by, Kohn, 1975), sibiromycin (see a review by Gause, 1975), tomaymycin (Arimaet al., 1972) and mazethramycin (Kunimotoet al., 1980) belong to. Neothramycin1 contains two stereoisomers A and B in nearly equal amounts. The structural elucidation and total synthesis have been reported by Miyamoto et al. (1977). Both antibiotics are hydrated within 60 min after being dissolved in water, forming the 10-hydro-ll-hydroxyl-derivatives (Fig. 1). The hydroxyl groups at C-3 and C-ll epimerize in aqueous solution.

Keywords

Leukemia Bacillus Sarcoma Dehydration Pseudomonas 

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© Springer-Verlag Berlin · Heidelberg 1983

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  • N. Tanaka

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