Abstract
We have found a number of novel inhibitors of protein synthesis by eukaryotic cells in a screening program including axenomycin B, A201A, bouvardin, cyclopiazonic acid, grandilactones A and B, holacanthone, and 6,6′-dihydroxy-thionuphlutine (Table 1)
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References
Arcamone F, Barbeien W, Franceschi G, Penco S, Vigevani A (1973) Axenomycin. I. The structure of chromophore and sugar moieties. J Am Chem Soc 95: 2008–2009
Bianchi M, Cotta E, Fermi G, Grein A, Julita P, Mazzoleni R, Spalla C (1974) Axenomycins, new anthelmintic, antiprotozoal and antifungal antibiotics produced by Streptomyces lisandri nov. sp. Arch Microbiol 98: 289–299
Chitnis MP, Alate AD, Menon RS (1981) Effect of bouvardin (NSC 259968) on the growth characteristics and nucleic acids and protein synthesis profiles of P388 leukemia cells. Chemotherapy 27: 126–130
Cullen WP, La Londe RT, Wang CJ, Wong CF (1973) Isolation and in vitro antifundal activity of 6,6’-dihydroxythiobinupharidme. J Pharm Sci 62: 826–827
Dolz H, Vázquez D, Jiménez A (1982) Quantitation of the specific interaction of (14a-3H)cryptopleur- ine with 80S and 40S ribosomal species from the yeast Saccharomyces cerevisiae. Biochemistry 21: 3181–3187
Epp JK, Allen NE (1976) A201A, a new antibiotic produced by Streptomyces capreolus. IV. Mode of action. 16th Annu IACCA Meet 1976, abstr 63
Fresno M, González A, Vázquez D, Jiménez A (1977) Bruceantin, novel inhibitor of peptide bond formation. Biochim Biophys Acta 518: 104–112
González A, Jiménez A, Vázquez D, Davies JE, Schindler D (1978) Studies on the mode of action of hygromycin B. and inhibitor of translocatin in eukaryots. Biochim Biophys Acta 521: 459–469
Hamill RL, Hoehn MM (1976) A201A, a new antibiotic produced by Streptomyces capreolus. I. Discovery isolation and properties. 16th Annu IACCA Meet 1976, abstr 60
Hartwell JL (1976) Types of anticancer agents isolated from plants. Cancer Treat Rep 60: 1031–1067
Holzapfel CW (1968) The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicil-lium cyclopium westling. Tetrahedron 24: 2101–2108
Jiménez A, Carrasco L, Vázquez D (1977) Enzymic and non enzymic translocation by yeast polysomes. Site of action of a number of inhibitors. Biochemistry 16: 4727–4730
Jolad SD, Hoffmann JJ, Torrance SJ, Wiedhopf RM, Cole JR, Arora SK, Bates RB, Gargiuro RL, Kicek GR (1977) Bouvardin and deoxybouvardin, antitumor cyclic hexapeptides from Bouvardia ternifolia ( Rubiaceae ). J Am Chem Soc 99: 8040–8044
La Londe RT, Wong CF, Das KC (1973) Thiospiran, C30, Nuphar alkaloids. Structure and evidence for intramolecular sulfur-immonium ion interactions. J Am Chem Soc 95: 6342–6349
Lee K, Imakura Y, Sumida Y, Wu R, Hall IH, Huang H (1979) Antitumor agents. 33. Isolation and structural elucidation of bruceoside-A and -B, novel antileukemic quassinoid glycosides, and bruccin-D and -E from Brucea javanica. J Org Chem 44: 2180–2185
Liao LL, Kupchan SM, Horwitz SB (1976) Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis. Mol Pharmacol 12: 167–176
Muñoz A, Carrasco L (1981) Protein synthesis and membrane integrity in interferon-treated HeLa cells infected with encephalomycocarditis virus. J Gen Virol 56: 153–162
Pierré A, Robert-Géro M, Tempete C, Polonski J (1980) Structural requirements of quassinoids for the inhibition of cell transformation. Biochem Biophys Res Commun 93: 675–686
Polonsky J, Waron Z, Moretti C, Pettit GR, Herald CL, Rideout J A (1980) J Nat Prod 43: 503–509
Purchase IFH (1974) Penicillium cyclopium. In: Purchase IFH (ed) Purchase IFH, pp 149–162. Elsevier,Amsterdam Oxford New York
Sora S, Ciferri O, Di Pascale G, Magni GE (1980) Genetics and biochemistry of resistance to axenomycin in Saccharomyces cerevisiae. Curr Genet 2: 61–67
Suhadolnik RJ (1979) Naturally occurring nucleosides and nucleotide antibiotics. Prog Nucleic Acid Res Mol Biol 23: 193–291
Vázquez D (1979) Inhibitors of protein biosynthesis. Springer, Berlin Heidelberg New York
Wall ME, Wani MC, Taylor H (1976) Iolation and chemical characterization of antitumor agents from plants. Cancer Treat Rep 60: 1011–1030
Willingham W Jr, Stafford EA, Reynolds SH, Shaney SG, Lee K, Okano M, Hall IH (1981) Mechanism of eukaryotic protein synthesis inhibition by brusatol. Biochim Biophys Acta 654: 169–174
Zalacain M, Zaera E, Vázquez D, Jiménez A (1982) The mode of action of the antitumor drag bouvardin, an inhibitor of protein synthesis in eukaryotic cells. FEBS Letters 148: 95–97
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Jiménez, A., Vázquez, D. (1983). Novel Inhibitors of Translation in Eukaryotic Systems. In: Hahn, F.E. (eds) Modes and Mechanisms of Microbial Growth Inhibitors. Antibiotics, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68946-8_16
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DOI: https://doi.org/10.1007/978-3-642-68946-8_16
Publisher Name: Springer, Berlin, Heidelberg
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