Retroviruses 1 pp 127-146 | Cite as

Molecular and Cellular Biology of Abelson Virus Transformation

  • Owen N. Witte
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 103)


A tremendous increase in our knowledge of the variety of retroviral transforming genes and their complexity of structure and function has been attained within the last decade. Rapidly transforming, replication-defective retroviruses have gained a prominent position as systems to exploit in the study of the interactions of specific growth control genes and their host cells. A large number of independent isolates of such viruses from diverse vertebrate species (see Coffin et a1.1980) have been documented. The phenomenon of a specific host cell gene being recombined with part of the sequences of a replication-competent retrovirus and, hence, generating a new viral form and function has been demonstrated at the biological and molecular levels for a number of cases.


Natl Cancer Inst Murine Leukemia Virus Helper Virus Synthetic Peptide Substrate Abelson Murine Leukemia Virus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Owen N. Witte
    • 1
  1. 1.Department of Microbiology and Molecular Biology InstituteUniversity of CaliforniaLos AngelesUSA

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