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Retroviruses 1 pp 127-146 | Cite as

Molecular and Cellular Biology of Abelson Virus Transformation

  • Owen N. Witte
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 103)

Overview

A tremendous increase in our knowledge of the variety of retroviral transforming genes and their complexity of structure and function has been attained within the last decade. Rapidly transforming, replication-defective retroviruses have gained a prominent position as systems to exploit in the study of the interactions of specific growth control genes and their host cells. A large number of independent isolates of such viruses from diverse vertebrate species (see Coffin et a1.1980) have been documented. The phenomenon of a specific host cell gene being recombined with part of the sequences of a replication-competent retrovirus and, hence, generating a new viral form and function has been demonstrated at the biological and molecular levels for a number of cases.

Keywords

Natl Cancer Inst Murine Leukemia Virus Helper Virus Synthetic Peptide Substrate Abelson Murine Leukemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Owen N. Witte
    • 1
  1. 1.Department of Microbiology and Molecular Biology InstituteUniversity of CaliforniaLos AngelesUSA

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