Analysis of Two Monoclonal Antibodies Defining the Majority and a Subset of Human T Cells
The introduction of hybridoma technology has revolutionised the identification and separation of human T cell subpopulations. In general, specific monoclonal antibodies have been shown to react with either all of the T cells (pan), an inducer subset or a cytotoxic/suppressor subset. In this article we describe the characteristics of two new monoclonal antibodies which react with the majority (MID 5) and a subpopulation of T cells (MID 4).
KeywordsChronic Lymphocytic Leukaemia Ascitic Fluid Cell Subpopulation Chronic Lymphocytic Leukaemia Cell Monoclonal Cell
Unable to display preview. Download preview PDF.
- 2.Reverley PCL, Callard RE (1981) Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol 11: 329–334Google Scholar
- 3.Beverley PCL, Callard RE (1981) Re-definition of human T cells by monoclonal antibodies. In: Peeters E (ed), Protides of the Biological Fluids, vol. 29, Pergamon Press, Oxford.Google Scholar
- 4.Beverley PCL (1982) The application of monoclonal antibodies to the typing and isolation of lymphoreticular cells. Proc Roy Soc (Edinburgh) 81 B: 221–232.Google Scholar
- 5.Fischer A, Beverley PCL, Feldmann M, Smith S (1988) Induction of a T cell mediated suppressor activity by soluble products for antigen-specific helper/inducer human T cell lines. Immunol (in press)Google Scholar