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The Dualism of Expression of onc-Genes: Transformation versus Differentiation

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Biochemistry of Differentiation and Morphogenesis

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Abstract

Tumor cells differ from their normal counterparts in two important functional properties: they are capable of indefinite proliferation and they display a more or less drastically altered metabolism. The fundamental molecular mechanisms responsible for these dramatic pheno-typic changes are not yet understood, but can be directly investigated by the use of tumor viruses. Many tumor viruses are known which contain a so-called onc or tumor gene that is solely responsible for tumor formation in vivo and cell transformation in vitro. Some of these genes have been named according to the histopathological type of tumor they induce, for instance myb for a gene which induces myeloblastosis and src for one which results in a sarcoma (Coffin et al. 1981). Of special interest are the RNA tumor viruses, because homologous counterparts of the onc gene of these viruses are found in the genome of normal cells (Bishop 1981). These cellular onc genes (c-onc) are not only detected in the natural host of the virus but also in other animal species, having been highly conserved during evolution.

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Authors and Affiliations

  1. Institut für Virologie, Fachbereich Humanmedizin, Justus-Liebig-Universität Giessen, Frankfurter Str. 107, D-6300, Giessen, Germany

    A. Ziemiecki

Authors
  1. H. Bauer
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  2. A. Barnekow
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  3. C. B. Boschek
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  4. R. R. Friis
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  5. A. Ziemiecki
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Editor information

Editors and Affiliations

  1. Institut für Biochemie der Universität zu Köln, An der Bottmühle 2, D-5000, Köln 1, Germany

    Lothar Jaenicke

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© 1982 Springer-Verlag Berlin Heidelberg

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Bauer, H., Barnekow, A., Boschek, C.B., Friis, R.R., Ziemiecki, A. (1982). The Dualism of Expression of onc-Genes: Transformation versus Differentiation. In: Jaenicke, L. (eds) Biochemistry of Differentiation and Morphogenesis. Colloquium der Gesellschaft für Biologische Chemie 25.–27. März 1982 in Mosbach/Baden, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68833-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-68833-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68835-5

  • Online ISBN: 978-3-642-68833-1

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