Altered Cell Surface Glycosphingolipids of Murine Lymphocytes Belonging to Different Differentiation Pathways

  • P. F. Mühlradt
  • B. Kniep
  • R. G. Gruner
Part of the Colloquium der Gesellschaft für Biologische Chemie 25.–27. März 1982 in Mosbach/Baden book series (MOSBACH, volume 33)


The very early stages of differentiation of lymphocytes are associated with migrations from primary to secondary lymphoid organs. Thus T lymphocytes, which like all other blood cells originate from the bone marrow, spend some of their early life time in the thymus gland (which is why they are called “T cells”), where they mature and learn to discriminate self from nonself, i.e. own tissue from foreign tissue. After “graduation” they leave the thymus and home to specific areas in lymph nodes and spleen. Other, less sessile lymphocytes, circulate with blood and lymph in the body to watch for foreign substances, invading microorganisms or tumor cells.


Lymphocyte Subpopulation Mixed Lymphocyte Reaction Mixed Lymphocyte Culture High Performance Liquid Chromato Mouse Thymocyte 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • P. F. Mühlradt
  • B. Kniep
  • R. G. Gruner
    • 1
  1. 1.Gesellschaft für Biotechnologische Forschung mbH (GBF)Braunschweig-StöckheimGermany

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