Advertisement

Multicentre Pilot Study for Therapy of Acute Lymphoblastic and Acute Undifferentiated Leukemia in Adults

  • D. Hoelzer
  • E. Thiel
  • H. Löffler
  • H. Bodenstein
  • T. Büchner
  • D. Messerer
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)

Abstract

In 1978 a study group was formed in the Federal Republic of Germany for the treatment of acute lymphoblastic leukemia (ALL) und acute undifferentiated leukemia (AUL) in adults. A modified form of an intensive induction and consolidation regimen successful in children with ALL [1] was used. The objective was to determine whether a prolonged remission induction and the addition of the drugs cyclophosphamide, cytosine-arabinoside and 6-mercaptopurine to the more conventional drugs for induction therapy of ALL, vincristine, prednisone, daunorubicin and L-asparaginase would improve the longterm results. It was hoped that a large number of hospitals would participate and that, with a sufficient number of patients uniformly treated, it would be possible to determine prognostic factors and to identify risk groups. This report concerns the design of the study, the toxicity of the therapeutic regimen and the first results.

Keywords

Acute Lymphoblastic Leukemia Induction Therapy Bone Marrow Smear Longterm Result Naphthyl Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. 1.
    Riehm H, Gadner H, Henze G, Langermann H-J, Odenwald E (1980) The Berlin childhood acute lymphoblastic leukemia therapy study, 1970–1976. Am J Pediatr Hematol Oncol 2:299–306Google Scholar
  2. 2.
    Loeffler H (1975) Biochemical properties of leukemia blast cells revealed by cytochemical methods: their relation to prognosis. In: Fliedner TM, Perry S (eds) Prognostic factors in human acute leukemia. Advances in the biosciences, vol 14. Pergamon Press, Vieweg & Sohn, Braunschweig, pp 163–173Google Scholar
  3. 3.
    Thiel E, Rodt H, Huhn D, Netzel B, Grosse-Wilde H, Ganeshaguru K, Thierfelder S (1980) Multimarker classification of acute lymphoblastic leukemia: evidence for further T subgroups and evaluation of their clinical significance. Blood 56: 759–772PubMedGoogle Scholar
  4. 4.
    Kaplan EL, Meier P (1978) Nonparametric estimation for incomplete observations. J Am Stat Assoc 53:457–481CrossRefGoogle Scholar
  5. 5.
    Esterhay RJ, Wiernik PH, Grove WR, Markus SD, Wesley MN (1982) Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. Blood 59: 334–345PubMedGoogle Scholar
  6. 6.
    Clarkson B, Schauer P, Mertelsmann R, Gee T, Arlin Z, Kempin S, Dowling M, Dufour P, Cirrincione C, Burchenal JH (1981) Results of intensive treatment of acute lymphoblastic leukemia in adults. In: Cancer. Achievements, challenges and prospects for the 1980s, vol. 2. Grune & Stratton, New York, London, pp 301–317Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • D. Hoelzer
  • E. Thiel
  • H. Löffler
  • H. Bodenstein
  • T. Büchner
  • D. Messerer

There are no affiliations available

Personalised recommendations