Detection of Group and Interspecies Reactivities in Mammalian C-Type Virus p30 Proteins and Corresponding Human Antigens

  • H. Schetters
  • V. Erfle
  • R. Hehlmann
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)


We previously reported the presence of RNA tumor virus related antigens in human leukemic sera. The antigens were detected by the ELISA method in 30%–40% of patients with acute leukemia [1, 2]. Since these antigens from human sera that cross-react with primate C-type viral p30 protein had been observed with the ELISA method and since retroviral group and interspecies reactivities had been previously characterized mostly by competition radioimmunoassay, we examined the applicability and reliability of the ELISA method for the detection of group and interspecific determinants in p30 proteins of mammalian C-type retroviruses [4].


Albumin Leukemia Lipase Polyacrylamide Transferrin 


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  1. 1.
    Hehlmann R, Schetters H, Erfle V (1981) ELISA for the detection of antigens cross-reacting with primate C-type viral proteins (p30, gp70) in human leukemic sera, in haematology and blood transfusion. In: Neth, Gallo, Graf, Mannweiler, Winkler (eds) Modern trends in human leukemia IV. Springer, Berlin Heidelberg New York, vol 26, pp 530–536Google Scholar
  2. 2.
    Hehlmann R, Schetters H, Erfle V, Leib-Mösch C (1983) Detection and biochemical characterization of antigens in human leukemic sera that crossreact with primate Ctype viral p30 proteins. Cancer Res (in press)Google Scholar
  3. 3.
    Schetters H, Hehlmann R, Erfle V, Ramanarayanan M (1980) Detection and quantification of type C viral proteins in tissues and sera with an enzyme immunoassay. Infect Immun 29:972–980PubMedGoogle Scholar
  4. 4.
    Schetters H, Hehlmann R, Erfle V, Saxinger C (1982) Detection of group and interspecies reactivities of mammalian C-type virus p30 proteins by an enzyme immunoassay (ELISA). J Virol Meth (in press)Google Scholar
  5. 5.
    Schetters H, Hehlmann R, Erfle V, Leib-Mösch C, Weber W (to be published) Further serological and peptide analysis of human antigens that crossreact with primate C-type viral p30 proteinsGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • H. Schetters
  • V. Erfle
  • R. Hehlmann

There are no affiliations available

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