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The Biology of an Oncogene, Based Upon Studies on Neoplasia in Xiphophorus

  • F. Anders
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)

Abstract

Xiphophorus, including swordtails and platyfish, is a genus of small viviparous freshwater fish from Central America that serves increasingly as a laboratory animal [1]. For 25 years we have used Xiphophorus for studies on neoplasia, which can easily be induced in hybrids between descendants of different provenance [2]. Although neoplasia of these animals is rather well understood in terms of formal genetics, the molecular basis of this phenomenon was extremely resistant to any elucidation. Recently a promising approach to the study of neoplasia in Xiphophorus at the molecular level has been undertaken in a cooperative work of the laboratories of H. Bauer (Institut für Virologie, Giessen), W. and H. Kersten (Institut für Physiologische Chemie, Erlangen), S. Nishimura (National Cancer Center Research Institute, Tokyo), and our laboratories. The present review will trace some steps of our studies that led to the detection of a cellular oncogene and a prominent regulatory gene.

Keywords

Pigment Cell Dosage Compensation Tumor Gene Rous Sarcoma Virus Amelanotic Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kallman K (1975) In: King RC (ed) Handbook of Genetics, vol 4, p 81, Plenum Press, New YorkCrossRefGoogle Scholar
  2. 2.
    Anders A, Anders F (1978) Biochim Biophys Acta 516:61PubMedGoogle Scholar
  3. 3.
    Rosen D (1979) Bull Amer Nat Hist 162:267Google Scholar
  4. 4.
    Schwab M (1980) Verh Dtsch Zool Ges 73:285Google Scholar
  5. 5.
    Scholl A, Anders F (1973) Archiv für Genetik 46: 121PubMedGoogle Scholar
  6. 6.
    Scholl E (1980) Thesis, GiessenGoogle Scholar
  7. 7.
    Kollinger G, Siegmund E (1981) Verh Dtsch Zool Ges 74:206Google Scholar
  8. 8.
    Anders F, Schartl M, Scholl E (1981) In: Dawe C et al. (eds) Phyletic Approaches to Cancer. Japan Sci Soc Press, Tokyo, p 189Google Scholar
  9. 9.
    Schwab M, Haas J, Abdo S, Ahuja MR, Kollinger G, Anders A, Anders F (1978) Experientia 34: 780PubMedCrossRefGoogle Scholar
  10. 10.
    Schwab M, Abdo S, Ahuja MR, Kollinger G, Anders A, Anders F, Frese K (1978) Z Krebsforsch 91:301CrossRefGoogle Scholar
  11. 11.
    Prescott DM, Flexer AS (1982) Cancer: The Misguided Cell, Sinauer Associate Inc. Publishers, Sunderland, MassGoogle Scholar
  12. 12.
    Heston WE (1974) Heredity 65:262Google Scholar
  13. 13.
    Anders A, Anders F, Kline K (1973) In: Schröder JH (ed) Genetics and Mutagenesis of Fish, I 33, II 53, Springer, Berlin Heidelberg New YorkGoogle Scholar
  14. 14.
    Ahuja MR, Schwab M, Anders F (1980) J of Heredity 71:403Google Scholar
  15. 15.
    Siciliano MJ, Wright DA (1976) Prog Exp Tumor Res 20: 398PubMedGoogle Scholar
  16. 16.
    Anders F, Schwab M, Scholl E (1981) In: Stich HF, San R (eds) Short Term Tests for Chemical Carcinogens, Springer, Berlin Heidelberg New York, p 399CrossRefGoogle Scholar
  17. 17.
    Vielkind J, Vielkind U, Anders F (1971) Z Krebsforsch 75:243PubMedCrossRefGoogle Scholar
  18. 18.
    Vielkind U, Schlage W, Anders F (1977) Z Krebsforsch 90:285CrossRefGoogle Scholar
  19. 19.
    Anders F, Diehl H, Schwab M, Anders A (1979) In: Klaus SN (ed) Pigmentation, its Genesis and Biological Control, vol 4, p 142Google Scholar
  20. 20.
    Anders F, Diehl H, Scholl E (1980) In: Spearman RIC, Riley PA (eds) The Skin of Vertrebrates, Linnean Society Symposium Series Number 9. Academic Press, London p 211Google Scholar
  21. 21.
    Schartl M, Schartl A, Anders A (1981) In: Seiji M (ed) Pigment Cell, University of Tokyo Press, p 507Google Scholar
  22. 22.
    Ahuja MR, Lepper K, Anders F (1979) Experientia 35:28PubMedCrossRefGoogle Scholar
  23. 23.
    Anders F, Klinke K (1966) Verh Dtsch Zool Ges 30:391Google Scholar
  24. 24.
    Schwab M, Vielkind J, Anders F (1976) Mol Gen Genet 144: 151PubMedCrossRefGoogle Scholar
  25. 25.
    Vielkind J, Haas-Andela H, Vielkind U, Anders F (1982) Mol Gen Genet 185:379PubMedCrossRefGoogle Scholar
  26. 26.
    Wigler M, Pellicer A, Silverstein S, Axel R (1978) Cell 14:725PubMedCrossRefGoogle Scholar
  27. 27.
    Willecke K (1980) In: Celis JE, Graessmann A, Loyter A (eds) Transfer of Cell Constituents into Eukaryotic Cells. Plenum Press, New York, London, p 311Google Scholar
  28. 28.
    Stehelin D, Varmus HE, Bishop JM (1976) Nature 260: 170PubMedCrossRefGoogle Scholar
  29. 29.
    Spector DH, Varmus HE, Bishop JM (1978) Proc Natl Acad Sci Wash 75:4102CrossRefGoogle Scholar
  30. 30.
    Bauer H, 33. Kolloquium Mosbach 1982. (in press)Google Scholar
  31. 31.
    Barnekow A, Schartl M, Anders F, Bauer H (1982) Cancer Res 42:2429PubMedGoogle Scholar
  32. 32.
    Czernofsky AP, Schartl M (unpublished)Google Scholar
  33. 33.
    Collett MS, Purchio AF, Erikson RL (1980) Nature 285: 167PubMedCrossRefGoogle Scholar
  34. 34.
    Schartl M, Barnekow A, Bauer H, Anders F (1982) Cancer Res 42:4222PubMedGoogle Scholar
  35. 35.
    Chatterjee K, Kollinger G, Schmidt R-C, Anders A, Anders F (1981) Cancer Genetics and Cytogenetics 3: 195PubMedCrossRefGoogle Scholar
  36. 36.
    Schartl M, Barnekow A (unpublished)Google Scholar
  37. 37.
    Shilo BZ, Weinberg RA (1981) Proc Natl Acad Sci Wash 78:6789CrossRefGoogle Scholar
  38. 38.
    Vielkind U (1976) J Exp Zool 196: 197PubMedCrossRefGoogle Scholar
  39. 39.
    Schartl M (1979) Thesis, GiessenGoogle Scholar
  40. 40.
    Kersten H, 33. Colloquium Mosbach 1982. (in press)Google Scholar
  41. 41.
    Okada N, Shindo-Okada N, Sato Sh, Itoh YH, Oda K-I, Nishimura S (1978) Proc Natl Acad Sci Wash 75:4247CrossRefGoogle Scholar
  42. 42.
    Kersten H (1982) In: Usdin E, Borchardt R, Greveling B (eds) Elsevier North-Holland Inc (in press)Google Scholar
  43. 43.
    Kersten H (in press) J of Cancer Res and Clinical OncologyGoogle Scholar
  44. 44.
    Shindo-Ikada N, Terada M, Nishimura S (1981) Eur J Biochem 115:423PubMedCrossRefGoogle Scholar
  45. 45.
    Kasai H, Kuchino Y, Nhei K, Nishimura S (1975) Nucl Acids Res 2: 1931PubMedCrossRefGoogle Scholar
  46. 46.
    Dess G (1982) Thesis, GiessenGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • F. Anders

There are no affiliations available

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