Dysfunctional Glucocorticoid Receptors in Acute Leukemia

  • R. Bell
  • A. Lillquist
  • S. Cotter
  • S. Sallan
  • R. McCaffrey
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)


The obligatory role of specific cytoplasmic receptors as mediators of steroid hormone action is well established. In lymphoid cell culture systems the development or glucocorticoid resistance is almost always due to a mutation to a receptor negative state [1]. Therefore, if the assumption is that glucocorticoid-induced remission in leukemia is by a direct effect on leukemic blast cells, one would predict that the presence of absence of blast cell glucocorticoid receptors would be a major determinant or clinical steroid sensitivity. However, receptor quantization has not correlated with steroid responsiveness [2–5], and in particular, high receptor numbers are not uniformly associated with responsive disease [6].


Acute Lymphoblastic Leukemia Glucocorticoid Receptor Acute Leukemia Blast Cell Human Peripheral Blood Lymphocyte 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • R. Bell
  • A. Lillquist
  • S. Cotter
  • S. Sallan
  • R. McCaffrey

There are no affiliations available

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