Multimarker Analysis of Childhood Acute Lymphoblastic Leukemia (ALL): Heterogeneity of Cellular Phenotypes and Clinical Relevance of Immunological Defined ALL Subclasses

  • I. Thoene
  • H. Kabisch
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)


The comparative study of normal and leukemic cells by means of immunological phenotyping has provided insights into the origin of the malignant cell clones and the putative “target” cells of malignant transformation. The similarity found between normal and leukemic cell phenotypes suggests that leukemic blasts represent lymphoid cells which are arrested at a given stage along the individual differentiation pathway [4].


Acute Lymphoblastic Leukemia Childhood Acute Lymphoblastic Leukemia Peanut Agglutinin Immunological Phenotyping Rosette Assay 
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  1. 1.
    Abramson CS, Kersey JH, LeBien TW (1981) A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage. J Immunol 126:83–88PubMedGoogle Scholar
  2. 2.
    Bollum FJ (1975) Antibody to terminal deoxynucleotidyl transferase. Proc Natl Acad Sci USA 72:4119–4122PubMedCrossRefGoogle Scholar
  3. 3.
    Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer MF (1979) Hybrid myeloma monoclonal antibodies against MHL products. Immunol Rev 47:3–61PubMedCrossRefGoogle Scholar
  4. 4.
    Greaves MF, Janossy G (1978) Patterns of gene expression and cellular origin of human leukemias. Biochim Biophys Acta 516: 193–230PubMedGoogle Scholar
  5. 5.
    Greaves MF, Janossy G, Francis GE, Minowada J (1978) Membrane phenotypes of human leukemic cells and leukemic cell lines. Clinical correlations and biological implications. In: Differentiation of normal and neoplastic hematopoietic cells. Cold Spring Harbor Laboratories, pp 823–41Google Scholar
  6. 6.
    Gudat FG, Forster HK, Girard MF, Albrecht R, Ludwig C, Obrecht JP (1981) Recognition of leukemic B-lymphoma cells by monoclonal anti-Y29/55. In: Knapp W (ed) Leukemia markers. Academic Press, pp 109–12Google Scholar
  7. 7.
    Janossy G, Bollum FJ, Bradstock KF, McMichael A, Rapson N, Greaves MF (1979) Terminal transferase positive human bone marrow cell exhibits the antigenic phenotype of common acute lymphoblastic leukemia (ALL). J Immunol 123: 1525–1528PubMedGoogle Scholar
  8. 8.
    Kersey JH, LeBien WT, Abramson CS, Newman R, Sutherland R, Greaves MF (1981) P 24: a human leukemia-associated and lymphohemopietic progenitor cell surface structure identified with monoclonal antibody. J Exp Med 153:726–731PubMedCrossRefGoogle Scholar
  9. 9.
    Korsmeyer SJ, Hieter PA, Ravetch JV, Poplack DG, Leder P, Waldmann TA (1981) Patterns of immunoglobulin gene arrangement in human lymphocytic leukemias. In: Knapp W (ed) Leukemia markers. Academic Press, pp 85–97Google Scholar
  10. 10.
    Liszka K, Majdic O, Bettelheim P, Knapp W (1981) A monoclonal antibody (VIL-A1) reactive with common acute lymphatic leukemia (CALL) cells. In: Knapp W (ed) Leukemia markers. Academic Press, pp 61–64Google Scholar
  11. 11.
    Ritz J, Pesando JM, Notis-McConarty J, Lazarus H, Schlossman SF (1980) A monoclonal antibody to human acute lymphoblastic leukemia antigen. Nature 283:583PubMedCrossRefGoogle Scholar
  12. 12.
    Thoene I (1982) Correspondence between the distribution of peanut agglutinin receptors and terminal transferase expression of human normal and leukemic cells (Abstract). J Clin Chem Clin Biochem 20: 133Google Scholar
  13. 13.
    Vogler LB, Christ WM, Bockman DE, Pearl AR, Lewton AR, Cooper MD (1978) Pre-B cell leukemia: a new phenotype of childhood lymphoblastic leukemia. N Engl; J Med 298: 872–878PubMedCrossRefGoogle Scholar
  14. 14.
    Winkler K, Matzke E, Caspers S, Erttmann R, Grosch-Wörner I, Kabisch H, Müller J, Landbeck G (1981) Vorstellung der kooperativen Studie COALL-80 zur Behandlung der akuten lymphoblastischen Leukämie im Kindesalter. Klin Päd 193:41–45CrossRefGoogle Scholar
  15. 15.
    Winkler K, Beron G, Thoene J, Jürgens H, Goebel U, Gutjahr P, Spaar HJ, Drescher J, Thomas P, Landbeck G (to be published) Therapie der ALL im KindesalterGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • I. Thoene
  • H. Kabisch

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