Abstract
Therapy for human leukemia is currently limited by toxicity of chemoradiotherapy to normal bone marrow stem cells. This limitation can be circumvented by the prior removal and subsequent reinfusion of autologous bone marrow [1, 2]. In order for successful engraftment to occur, reinfused bone marrow must be pruged of leukemic cells ex vivo while the viability of stem cells remains intact. Monoclonal antibodies have the potential of providing this selective destructive effect.
Supported in part by Grants CA31685, CA25097, CA21737, CA23021, and AM24027 from the NIH, and by a Grant from the University of Minnesota Graduate School. T.W.L. was the recipient of New Investigator Award CA28526 from the NCI
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LeBien, T.W., Ash, R.C., Zanjani, E.D., Kersey, J.H. (1983). In Vitro Cytodestruction of Leukemic Cells in Human Bone Marrow Using a Cocktail of Monoclonal Antibodies. In: Neth, R., Gallo, R.C., Greaves, M.F., Moore, M.A.S., Winkler, K. (eds) Modern Trends in Human Leukemia V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68761-7_25
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DOI: https://doi.org/10.1007/978-3-642-68761-7_25
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