Secretion of Plasminogen Activators by Human Myeloid Leukemic Cells: Modulation and Therapeutic Correlations

  • E. L. Wilson
  • P. Jacobs
  • E. B. Dowdle
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)


Plasminogen activator (PA) synthesis and release are inducible cellular functions [1–7] that are subject to modulation by hormones, drugs, and other pharmacological compounds which act at a genetic level Normal granulocytes synthesize PA [8, 9] and it is known that human cells release, plasminogen activators of two distinct immunochemical types — one similar to urokinase and the other similar to tissue activator [10–13].


Plasminogen Activator Acute Myeloid Leukemic Fibrinolytic Activity Phorbol Myristate Acetate Acute Myeloid Leukemic Patient 
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  1. 1.
    Wünschmann-Henderson B, Astrup T (1974) Inhibition by hydrocortisone of plasminogen activator production in rat tongue organ cultures. Lab Invest 30:427PubMedGoogle Scholar
  2. 2.
    Wigler M, Ford JP, Weinstein IB (1975) Glucocorticoid inhibition of the fibrinolytic activity of tumour cells. In: Rifkin D, Reich E, Shaw E (eds) Proteases in biological control. Cold Spring Harbor, Cold Spring Harbor, NY, p 849Google Scholar
  3. 3.
    Vassalli JD, Hamilton J, Reich E (1977) Macrophage plasminogen activator; induction by concanavalin A and phorbol myristate acetate. Cell 11: 695PubMedCrossRefGoogle Scholar
  4. 4.
    Ossowski L, Biegel D, Reich E (1979) Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue. Cell 16: 929PubMedCrossRefGoogle Scholar
  5. 5.
    Mak TW, Rutledge G, Sutherland DJA (1976) Androgen-dependent fibrinolytic activity in a murine mammary carcinoma (Shionogi SC-115 cells) in vitro. Cell 7:223PubMedCrossRefGoogle Scholar
  6. 6.
    Wilson EL, Dowdle EB (1980) Effects of retinoids on normal and neoplastic human cells cultured in vitro. Cancer Res 40: 4817PubMedGoogle Scholar
  7. 7.
    Wilson EL, Reich E (1978) Plasminogen activator in chick fibroblasts: induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester. Cell 15:385PubMedCrossRefGoogle Scholar
  8. 8.
    Goldstein IM, Wünschmann B, Astrup T, Henderson ES (1971) Effects of bacterial endotoxin on the fibrinolytic activity of normal human leukocytes. Blood 37:447PubMedGoogle Scholar
  9. 9.
    Granelli-Piperno A, Vassalli J-D, Reich E (1977) Secretion of plasminogen activator by human polymorphonuclear leucocytes. J Exp Med 146: 1693PubMedCrossRefGoogle Scholar
  10. 10.
    Wilson EL, Becker MLB, Hoal EG, Dowdle EB (1980) Molecular species of plasminogen activators secreted by normal and neoplastic human cells. Cancer Res 40:933PubMedGoogle Scholar
  11. 11.
    Vetterlein D, Bell TE, Young PL, Roblin R (1980) Immunological quantitation and immunoadsorption of urokinase-like plasminogen activators secreted by human cells. J Biol Chem 255:2665Google Scholar
  12. 12.
    Markus G, Takita H, Carniolo SM, Corosanti JG, Evers JL, Hobika GH (1980) Content and characterization of plasminogen activators in human lung tumours and normal lung tissue. Cancer Res 40:841PubMedGoogle Scholar
  13. 13.
    Åstedt B, Wallén P, Aasted B (1979) Occurrence of both urokinase and tissue plasminogen activator in human seminal plasma. Thromb Res 16:463PubMedCrossRefGoogle Scholar
  14. 14.
    Wigler M, Weinstein IB (1976) Tumour promoter induces plasminogen activator. Nature 259:232PubMedCrossRefGoogle Scholar
  15. 15.
    Wilson EL, Reich E (1979) Modulation of plasminogen activator synthesis in chick embryo fibroblasts by cyclic nucleotides and phorbol myristate acetate. Cancer Res 39: 1579PubMedGoogle Scholar
  16. 16.
    Viaje A, Slaga TJ, Wigler M, Weinstein IB (1977) Effects of anti-inflammatory agents on mouse skin tumour promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation and production of plasminogen activator. Cancer Res 37: 1530PubMedGoogle Scholar
  17. 17.
    Troll W, Rossman T, Katz J, Levitz M (1975) Proteinases in tumour promotion and hormone action. In: Rifkin D, Reich E, Shaw E (eds) Proteases in biological control. Cold Spring Harbor, Cold Spring Harbor, NY, p 977Google Scholar
  18. 18.
    Rifkin D (1978) Plasminogen activator synthesis by cultured human embryonic lung cells: characterization of the suppressive effect of corticosteroids. J Cell Physiol 97:421PubMedCrossRefGoogle Scholar
  19. 19.
    Roblin R, Young PL (1980) Dexamethasone regulation of plasminogen activator in embryonic and tumour-derived human cells. Cancer Res 40:2706PubMedGoogle Scholar
  20. 20.
    Wilson EL, Jacobs P, Dowdle EB (to be published) The secretion of plasminogen activators by human myeloid leukemic cells in vitro. Blood (in press)Google Scholar
  21. 21.
    Wilson EL, Jacobs P, Dowdle EB (to be published) The effects of dexamethasone and tetradecanoyl phorbol acetate on plasminogen activator release by human acute myeloid leukemia cells. Blood (in press)Google Scholar
  22. 22.
    Wilson EL, Dowdle E (1978) Secretion of plasminogen activator by normal, reactive and neoplastic human tissues cultured in vitro. Int J Cancer 22: 390PubMedCrossRefGoogle Scholar
  23. 23.
    Vassalli J-D, Hamilton J, Reich E (1976) Macrophage plasminogen activator: modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors and cyclic nucleotides. Cell 8:271PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • E. L. Wilson
  • P. Jacobs
  • E. B. Dowdle

There are no affiliations available

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