Advertisement

Interferon in Acute Myelogenous Leukaemia: A Preliminary Report

  • A. Z. S. Rohatiner
  • F. Balkwill
  • T. A. Lister
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)

Abstract

Interferon has been shown to have an antiproliferative effect on leukaemic blast cells in vitro [1, 3, 4]. In short-term liquid culture, 50% inhibition of growth is achieved at IFN-α concentrations of 103 units/ml using myeloblasts derived from patients with acute myelogenous leukaemia (AML) [5]. Pharmacokinetic studies in patients receiving IFN-α by continuous intravenous infusion (i.v.i) have shown that it is possible to achieve serum concentrations of 103 units/ml at daily doses greater than 30 × 106 units/m2 [6].

Keywords

Acute Myelogenous Leukaemia Cytosine Arabinoside Bone Marrow Infiltration Leukaemic Blast Lymphoblastoid Interferon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Balkwill F, Oliver RTD (1977) Growth inhibitory effect of interferon on normal and malignant human haemopoietic cells. Int J Cancer 20:500PubMedCrossRefGoogle Scholar
  2. 2.
    Christofinis JG (1971) Biological characteristics of a cell line GL-V3 derived from the kidney of a vervet monkey: Ceropithecus aethiops. J Med Microbiol 3:251–258CrossRefGoogle Scholar
  3. 3.
    Gresser I, Brouty-Boye D, Thomas MT et al. (1970) A: Interferon cell division. I. Inhibition of the multiplication of mouse leukaemia L1210 cells in vitro by interferon preparations. Proc Natl Acad Sci USA 66:1052PubMedCrossRefGoogle Scholar
  4. 4.
    Lundgren E, Hillorn W, Holmberg D et al. (1980) Comparative study on the effects of fibroblast and leukocyte interferon on short-term cultures of leukaemic cells. Ann NY Acad Sci 350:628CrossRefGoogle Scholar
  5. 5.
    Rohatiner AZS, Balkwill F, Malpas JS, Lister TA (1981) A Phase I study of human lymphoblastoid interferon in patients with haematological malignancies. In: Neth R, Gallo RC, Graf T, Mannweiler K, Winkler K (eds) Modern Trends in Human Leukaemia IV. Springer-Verlag, Berlin Heidelberg New York, pp 63–67Google Scholar
  6. 6.
    Rohatiner AZS, Balkwill FR, Griffin DB, Malpas JS, Lister TA (1982) A Phase I study of human lymphoblastoid interferon administered by continuous intravenous infusion. Cancer Chemother and Pharmacol 9:97CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • A. Z. S. Rohatiner
  • F. Balkwill
  • T. A. Lister

There are no affiliations available

Personalised recommendations