Interferon in Acute Myelogenous Leukaemia: A Preliminary Report
Interferon has been shown to have an antiproliferative effect on leukaemic blast cells in vitro [1, 3, 4]. In short-term liquid culture, 50% inhibition of growth is achieved at IFN-α concentrations of 103 units/ml using myeloblasts derived from patients with acute myelogenous leukaemia (AML) . Pharmacokinetic studies in patients receiving IFN-α by continuous intravenous infusion (i.v.i) have shown that it is possible to achieve serum concentrations of 103 units/ml at daily doses greater than 30 × 106 units/m2 .
KeywordsToxicity Leukemia Pneumonia Influenza Interferon
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