Interferon in Acute Myelogenous Leukaemia: A Preliminary Report

  • A. Z. S. Rohatiner
  • F. Balkwill
  • T. A. Lister
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)


Interferon has been shown to have an antiproliferative effect on leukaemic blast cells in vitro [1, 3, 4]. In short-term liquid culture, 50% inhibition of growth is achieved at IFN-α concentrations of 103 units/ml using myeloblasts derived from patients with acute myelogenous leukaemia (AML) [5]. Pharmacokinetic studies in patients receiving IFN-α by continuous intravenous infusion (i.v.i) have shown that it is possible to achieve serum concentrations of 103 units/ml at daily doses greater than 30 × 106 units/m2 [6].


Acute Myelogenous Leukaemia Cytosine Arabinoside Bone Marrow Infiltration Leukaemic Blast Lymphoblastoid Interferon 
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  1. 1.
    Balkwill F, Oliver RTD (1977) Growth inhibitory effect of interferon on normal and malignant human haemopoietic cells. Int J Cancer 20:500PubMedCrossRefGoogle Scholar
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    Rohatiner AZS, Balkwill F, Malpas JS, Lister TA (1981) A Phase I study of human lymphoblastoid interferon in patients with haematological malignancies. In: Neth R, Gallo RC, Graf T, Mannweiler K, Winkler K (eds) Modern Trends in Human Leukaemia IV. Springer-Verlag, Berlin Heidelberg New York, pp 63–67Google Scholar
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    Rohatiner AZS, Balkwill FR, Griffin DB, Malpas JS, Lister TA (1982) A Phase I study of human lymphoblastoid interferon administered by continuous intravenous infusion. Cancer Chemother and Pharmacol 9:97CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • A. Z. S. Rohatiner
  • F. Balkwill
  • T. A. Lister

There are no affiliations available

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