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Animal Models in Hepatitis Research

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Clinical Hepatology

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Abstract

In man, acute viral hepatitis is commonly caused by at least three antigenically and biologically distinct viruses (for a general review, see Koff [1]). Type A hepatitis, previously referred to as short-incubation or infectious hepatitis, occurs as a result of infection with hepatitis A virus (HAV), a small, 27 nM RNA virus with many features in common with picornaviruses. The virus is spread primarily by the fecal-oral route and hepatitis A occurs both sporadically and in epidemics. As with other human hepatitis agents, infection with HAV may result in either no symptoms, typical acute viral hepatitis, or occasionally fulminant and fatal disease. Persistent infections and chronic hepatic disease have not been related to HAV infection.

The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense

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Author information

Authors and Affiliations

  1. Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Washington D.C., 20012, USA

    S. M. Lemon

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  1. S. M. Lemon
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Editors and Affiliations

  1. Department of Clinical Research, Heimhuder Straße 46, D-2000, Hamburg 13, Germany

    Géza Csomós M.D.

  2. School of Medicine, University of Vienna, Austria

    Heribert Thaler M.D. (Assoc. Professor, Head of the 4th Medical Department) (Assoc. Professor, Head of the 4th Medical Department)

  3. Wilhelminenspital of the City of Vienna, 16, Montlearstraße 37, A-1171, Vienna, Austria

    Heribert Thaler M.D. (Assoc. Professor, Head of the 4th Medical Department) (Assoc. Professor, Head of the 4th Medical Department)

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© 1983 Springer-Verlag Berlin Heidelberg

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Lemon, S.M. (1983). Animal Models in Hepatitis Research. In: Csomós, G., Thaler, H. (eds) Clinical Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68748-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-68748-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68750-1

  • Online ISBN: 978-3-642-68748-8

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