Advertisement

Chronische Exposition mit Inhalationsanaesthetika — eine Gesundheitsgefährdung des Anaesthesisten?

Nebenwirkungen von flüchtigen Anaesthetika auf das Anaesthesiepersonal unter besonderer Berücksichtigung des Mutterschutzgesetzes
  • R. Dudziak
Conference paper
Part of the Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine book series (A+I, volume 152)

Zusammenfassung

Nach den Bestimmungen des Mutterschutzgesetzes (§ 4) — MuSchG — därfen werdende Mätter nicht mit schweren körperlichen Arbeiten und nicht mit Arbeiten beschäftigt werden, bei denen sie schädlichen Einwirkungen von gesundheitsgefährdenden Stoffen oder Strahlen, von Staub, Gas oder Dämpfen, von Hitze, Kälte oder Nässe, Erschätterungen oder Lärm ausgesetzt werden. Diese Vorschriften wurden in den letzten Jahren auf die Tätigkeit von weiblichem Personal in Operationssälen, in denen Narkosen gemacht werden, ausgedehnt.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Baden JM, Kelley M, Wharton RS, Hitt BA, Simmon VF, Mazze RI (1977) Mutagenicity of halogenated Ether Anesthetics. Anesthesiology 46:346PubMedCrossRefGoogle Scholar
  2. 2.
    Baden JM, Brinkenhoff M, Wharton RS, Hitt BA, Simmon VF, Mazze RI (1976) Mutagenicity of Volatile Anesthetics. Anesthesiology 45:311PubMedCrossRefGoogle Scholar
  3. 3.
    Barlow S, McElhatton P et al. (1974) Effects of stress during pregnancy on plasma corticosterone levels and fetal development in the mouse. J Physiol (Lond) 55:239Google Scholar
  4. 4.
    Basford AB, Fink BR (1968) The teratogenicity of halothane in the rat. Anesthesiology 29:1167PubMedCrossRefGoogle Scholar
  5. 5.
    Bruce DL, Koepke JA (1966) Changes in granulopoiesis in the rat associated with prolonged halothane anesthesia. Anesthesiology 27:811PubMedCrossRefGoogle Scholar
  6. 6.
    Bruce DL, Eide KA, Linde HW et al. (1968) Causes of death among anesthesiologists: A 20-year survery. Anesthesiology 29:565PubMedCrossRefGoogle Scholar
  7. 7.
    Bruce DL (1972) Normal thymidine entry into halothane-treated lymphocytes. Anesthesiology 37: 588PubMedCrossRefGoogle Scholar
  8. 8.
    Bruce DL (1972) Halothane inhibition of phytohemagglutinin-induced transformation of lymphocytes. Anesthesiology 36:201PubMedCrossRefGoogle Scholar
  9. 9.
    Bruce DL (1973) Murine fertility unaffected by traces of Halothane. Anesthesiology 38:473PubMedCrossRefGoogle Scholar
  10. 10.
    Bruce DL (1974) Halothane effect on nuclear volume of PHA treated human lymphocytes. J Reticuloendothel Soc 15:497PubMedGoogle Scholar
  11. 11.
    Bruce DL (1975) Halothane inhibition of RNA and protein synthesis of PHA-treated human lymphocytes. Anesthesiology 41:11CrossRefGoogle Scholar
  12. 12.
    Bruce DL, Eide KA, Smith NJ et al. (1974) A prospective study of anesthesiologists mortality 1967–1971. Anesthesiology 41:71PubMedCrossRefGoogle Scholar
  13. 13.
    Burm AGL, Spierdijk J, Rejger RV Concentrations of anesthetic agents in the air in operating rooms. Anesthesia and Pharmacology. University Press, Leiden 1976Google Scholar
  14. 14.
    Bussard DA, Stoelting RK, Peterson CH, Ishaq M (1974) Fetal changes in hamsters anesthetized with nitrous oxide and halothane. Anesthesiology 41:275PubMedCrossRefGoogle Scholar
  15. 15.
    Chang LW, Lee YK, Dudley AW jr et al. (1975) Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure. Can Anaesth Soc J 22:330PubMedCrossRefGoogle Scholar
  16. 16.
    Coate WB, Ulland BM, Lewis TR (1979) Chronic exposure to low concentrations of halothane — nitrous oxide: lack of carcinogenic effect in the rat. Anesthesiology 50:306PubMedCrossRefGoogle Scholar
  17. 17.
    Coate WB, Kapp RW, Lewis TR (1979) Chronic exposure to low concentrations of Halothane-Nitrous oxide. Reproductive and cytogenetic effects in the rat. Anesthesiology 50:310Google Scholar
  18. 18.
    Cohen EN (1976) Anesthetics and Cancer (editorial). Anesthesiology 44:459PubMedCrossRefGoogle Scholar
  19. 19.
    Cohen EN, Trudel JR, Edmunds HN, Watson E (1975) Urinary metabolites of Halothane in Man. Anesthesiology 43:392PubMedCrossRefGoogle Scholar
  20. 20.
    Cohen EN, Bellville JW, Brown BW (1971) Anesthesia, pregnancy and miscarriage: A study of operating room nurses and anesthetists. Anesthesiology 35:343PubMedCrossRefGoogle Scholar
  21. 21.
    Cohen EN, Brown BW, Bruce DL et al. (1974) Occupational disease among operating room personnel: A national study. Report on an Ad Hoc-Committee on the Effects of Trace Anesthetics on the health of Operating Room Personnel. Anesthesiology 41:321Google Scholar
  22. 22.
    Conklin KA, Shu-Sha Lau (1979) Halothane does not inhibit synthesis of nucleic acids in Terahymena pyriformis. Anesthesiology 51:508PubMedCrossRefGoogle Scholar
  23. 23.
    Corbett TH (1972) Anesthetics as a cause of abortion. Fertil Steril 23:866PubMedGoogle Scholar
  24. 24.
    Corbett TH, Cornell RG, Endres JL, Millard RI (1973) Effects of low concentrations of nitrous oxide on rat pregnancy. Anesthesiology 39:299PubMedCrossRefGoogle Scholar
  25. 25.
    Corbett TH, Cornell RG, Lieding K, Endres J (1973) Incidence of Cancer among Michigan Nurseanesthtists. Anesthesiology 38:261CrossRefGoogle Scholar
  26. 26.
    Corbett TH, Cornell RG, Endres JL, Lieding BSK (1974) Birth defects among children of nurseanesthetists. Anesthesiology 41:341PubMedCrossRefGoogle Scholar
  27. 27.
    Cullen BF, Sample WF, Chretien PB (1972) The effect of Halothane on phytohemagglutimin induced transformation of human lymphocytes in vitro. Anesthesiology 36:206PubMedCrossRefGoogle Scholar
  28. 28.
    Duvaldestin PH, Mazze RI, Hazebrougk J, Nivoche Y, Cohen SE, Desmonts JM (1979) Halothane Biotransformation in Anesthetists. Anesthesiology 51:41PubMedCrossRefGoogle Scholar
  29. 29.
    Dyke van RA (1978) Halothane — a new perspective. Anesthesiology 48:165PubMedCrossRefGoogle Scholar
  30. 30.
    Edmunds HN, Baden JM, Simmon VF (1979) Mutagenicity studies with volatile metabolites of halothane. Anesthesiology 51:424PubMedCrossRefGoogle Scholar
  31. 31.
    Eger EI (1979) Dragons and other scientific Hazards. Anesthesiology 50:1PubMedCrossRefGoogle Scholar
  32. 32.
    Eschenbrenner AB (1945) Induction of hematomas in mice by repeated administration of chloroforme with observation on sex differences. J Natl Canc Inst 5:251Google Scholar
  33. 33.
    Ferstanding LL (1978) Trace concentrations of anesthetics gases: A critical review of their disease potential. Anesth Analg 57:328Google Scholar
  34. 34.
    Fink BR, Cullen BF (1976) Anesthetic pollution: what is happening to us. Anesthesiology 45:79PubMedCrossRefGoogle Scholar
  35. 35.
    Fink BR, Shepard Th, Blandau RJ (1967) Teratogenic activity of nitrous oxide. Nature 214:146PubMedCrossRefGoogle Scholar
  36. 36.
    Garstka G, Wagner KL, Hamacher M (1975) Schwangerschaftskomplikationen bei Anästhesistinnen. Geburtsh u Frauenheilk 35:826Google Scholar
  37. 37.
    Green CD, Eastwood DN (1963) Effects of nitrous oxide inhalation on hemopoiesis in rats. Anesthesiology 24:341PubMedCrossRefGoogle Scholar
  38. 38.
    Hallén B, Johansson G (1975) Inhalation anesthetics and cytochrom P-450 dependent reactions in rat liver microsomes. Anesthesiology 43:34PubMedCrossRefGoogle Scholar
  39. 39.
    Hartung H, Oehmig H, Streicher HJ (1969) Histologische und biochemische Ergebnisse tierexperimenteller Untersuchungen zur Halothanlangzeitwirkung. Anaesthesist 18:255PubMedGoogle Scholar
  40. 40.
    Heintz R Erkrankungen durch Arzneimittel. 2. Aufl Georg Thieme Verlag, Stuttgart 1977Google Scholar
  41. 41.
    Jackson SH (1975) Anesthetics and cell multiplication. Clin Anesth 11:75PubMedGoogle Scholar
  42. 42.
    Jackson SH (1973) The metabolic effects of halothane on mammalian hepatoma cells in vitro. II. Inhibition of DNA synthesis. Anesthesiology 39:405Google Scholar
  43. 43.
    Kennedy GL, Smith SH, Keplinger ML et al. (1967) Reproductive and teratologic studies with halothane. Toxicol Appl Pharmacol 35:467CrossRefGoogle Scholar
  44. 44.
    Knill-Jones RP, Newman BJ, Spence AA (1975) Anesthetic practice and pregnancy. Lancet II 807CrossRefGoogle Scholar
  45. 45.
    Knill-Jones RP, Moir DB, Rodrigues LV et al. (1972) Anaesthetic practice and pregnancy: A controlled survey of women anesthetists in the United Kingdom. Lancet II, 1326CrossRefGoogle Scholar
  46. 46.
    Kramers PGN, Burm AGL (1979) Mutagenicity studies with halothane in Drosophila melanogaster. Anesthesiology 50:510PubMedCrossRefGoogle Scholar
  47. 47.
    Krapez JR, Saloojee Y, Hinds CJ, Hackett GH, Cole PV (1980) Blood concentrations of nitrous oxide in theatre personnel. Brit J Anaesth 52:1143PubMedCrossRefGoogle Scholar
  48. 48.
    Kripke BJ, Kelman AD, Shah NK et al. (1976) Testicular reaction to prolonged exposure to nitrous oxide. Anesthesiology 44:104PubMedCrossRefGoogle Scholar
  49. 49.
    Kunz W, Schaude G, Thomas C (1969) The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis. Z Krebsforsch 72:291PubMedCrossRefGoogle Scholar
  50. 50.
    Lansdown ABG, Pope WDB, Halsey MJ et al. (1976) Analysis of fetal development in rat following maternal exposure to subanesthetic concentrations of halothane. Teratology 13:299CrossRefGoogle Scholar
  51. 51.
    Lecky JH (1980) Anesthetic pollution in the operating room. A notice to operating room personnel. Anesthesiology 52:157Google Scholar
  52. 52.
    Linde HW, Bruce DL (1969) Occupational exposure of anesthetics to halothane, nitrous oxide and radiation. Anesthesiology 30:363PubMedCrossRefGoogle Scholar
  53. 53.
    Nunn JF, Allison AC Effects of anesthetics on microtubular system. Cellular Biology and Toxicology of Anesthetics. Edited by BR Finke, Baltimore, Williams & Wilkins, 1972, 138–148Google Scholar
  54. 54.
    Nunn JF, Dixon KL, Lovis JD (1969) The effects of halothane on mitosis. Anesthesiology 30:348CrossRefGoogle Scholar
  55. 55.
    Parbrook, GE (1967) Leucopenic effects of prolonged nitrous oxide treatment. Brit J Anaesth 39:119PubMedCrossRefGoogle Scholar
  56. 56.
    Pope WDB, Halsey MJ, Lansdown ABG et al. (1975) Lack of teratogenic dangers with halothane. Acta Anesthesiol Belg 26:169Google Scholar
  57. 57.
    Pope WDB, Halsey MJ, Lansdown ABG, Simmonds A, Bateman PE (1978) Fetotoxicity in rats following chronic exposure to halothane, nitrous oxide or methoxyflurane. Anesthesiology 48:11PubMedCrossRefGoogle Scholar
  58. 58.
    Saffioti U Memorandum alert. J Natl Cancer Inst March 21, 1975Google Scholar
  59. 59.
    Sharp JH, Trudell JR, Cohen EN (1979) Volatile metabolites and decomposition products of halothane in man. Anesthesiology 50:2PubMedCrossRefGoogle Scholar
  60. 60.
    Shepard TH, Fink BR Teratogenic activity of nitrous oxide in rats, toxicity of Anesthetics. Edited by BR Fink, Baltimore, Williams & Wilkins, 1968, p 308Google Scholar
  61. 61.
    Shnider SM, Webster AM (1968) Maternal and fetal hazards of surgery during pregnancy. Am J Obstet Gynecol 92:891Google Scholar
  62. 62.
    Smith BE, Gaub ML, Moya F (1965) Investigations into the teratogenic effects of anesthetic agents. The fluorinated agents. Anesthesiology 26:260Google Scholar
  63. 63.
    Smith BE, Gaub ML, Moya F (1965) Teratogenic effects of anesthetic agents. Nitrous oxide. Anesth Analg 44:726Google Scholar
  64. 64.
    Snegireff, SF, Andersen NB (1967) The growth inhibiting effect of nitrous oxide on developing chick embryos. Anesthesiology 28:268Google Scholar
  65. 65.
    Sturrock JE, Nunn JF (1976) Synergism between halothane of nuclear abnormalities in the dividing fibroblast. Anesthesiology 44:461PubMedCrossRefGoogle Scholar
  66. 66.
    Tesler A, Hinkley RE (1977) Cultured neuroblastoma cells and halothane: effects on all growth and macro-molecular synthesis. Anesthesiology 46:102CrossRefGoogle Scholar
  67. 67.
    Tomlin PJ (1979) Health problems of anaesthetics and their families in the West Midlands. Brit med J 1:779PubMedCrossRefGoogle Scholar
  68. 68.
    Vaisman AI (1967) Working conditions in surgery and their effect on the health of anesthesiologists. Eksp Khir Anestheziol 3:44Google Scholar
  69. 69.
    Vessey MP (1978) Epidemiological studies of the occupational hazards of anaesthesia. A review Anaesthesia 33:430Google Scholar
  70. 70.
    Wallin RF, Napoli MD, Regan BM: Laboratory investigation of a new series of inhalational anesthetic agents: the halomethyl polyfluoroisopropyl ethers. In: Cellular Biology and Toxicity of Anesthetics p 286–295Google Scholar
  71. 71.
    Walts LF, Forsythe AB, Moore JG (1975) Critique: Occupational disease among operating room personal. Anesthesiology 42:608PubMedCrossRefGoogle Scholar
  72. 72.
    Waskell L (1979) Lack of Mutagenicity of two possible metabolites of halothane. Anesthesiology 50:9PubMedCrossRefGoogle Scholar
  73. 73.
    Wharton RS, Wilson AI, Maze RI, Baden JM, Rice SA (1979) Fetal morphology in mice exposed to halothane. Anesthesiology 51:532PubMedCrossRefGoogle Scholar
  74. 74.
    Wharton RS, Mazze RI, Baden JM, Hitt BA, Dooley JR (1978) Fertility, reproduction and postnatal survival in mice chronically exposed to halothane. Anesthesiology 48:167PubMedCrossRefGoogle Scholar
  75. 75.
    Whitcher CE, Cohen EN, Trudell JR (1971) Chronic exposure to anesthetic gases in the operating room. Anesthesiology 35:348PubMedCrossRefGoogle Scholar
  76. 76.
    White AE, Takehisa S, Eger EI II, Wolff S, Stevens WC (1979) Sister chromatid Exchanges induced by inhaled anesthetics. Anesthesiology 50:426PubMedCrossRefGoogle Scholar
  77. 77.
    Widger LA, Gandolfi AJ, Dyke RA van (1979) Hypoxia and Halothane Metabolism in vivo. Release of inorganic Fluoride and Halothane Metabolite binding to cellular constituents. Anesthesiology 44:197Google Scholar
  78. 78.
    Wittmann R, Doenicke A, Heinrich H et al. (1974) Die abortive Wirkung von Halothane. Anaesthesist 23:30Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • R. Dudziak

There are no affiliations available

Personalised recommendations