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Mast Cell-Dependent Effector Pathways and Cutaneous Bullous Disorders

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Immunodermatology

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Abstract

Serum antibodies directed against epidermal antigens have been detected in patients with pemphigus vulgaris [2] and bullous pemphigoid [15]. These observations led to the hypothesis that these cutaneous blistering disorders may be autoimmune diseases in which antibody and complement participate to mediate the development of clinical lesions. Recent observations suggest that mast cell-initiated effector pathways may at least play a role in the pathogenesis of one these diseases, bullous pemphigoid [29]. This chapter considers the possible role of the mast cell in cutaneous inflammatory bullous disorders and proposes an alternative hypothesis to an autoimmune etiology for bullous pemphigoid.

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References

  1. Baba T, Sonozaki H, Seki K, Uchiyama M, Ikesawa Y, Torisu M (1976) An eosinophil chemotactic factor present in blister fluids of bullous pemphigoid patients. J Immunol 116: 112

    PubMed  CAS  Google Scholar 

  2. Beutner EH, Jordon RE (1964) Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining. Proc Soc Exp Biol Med 117: 505

    PubMed  CAS  Google Scholar 

  3. Boswell RN, Austen KF, Goetzl EJ (1978) Intermediate molecular weight eosinophil chemotactic factors in rat peritoneal mast cells: immunological release, granule association, and demonstration of structural heterogeneity. J Immunol 120: 15

    PubMed  CAS  Google Scholar 

  4. Center DM, Austen KF, Wintroub BU (1978) Identification of chemoattractant activity for lymphocytes in bullous pemphigoid bullous fluid. Trans Assoc Am Physicians 91: 242

    PubMed  CAS  Google Scholar 

  5. Cochrane CG, Müller-Eberhard HJ (1968) The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement. J Exp Med 127:371

    Article  PubMed  CAS  Google Scholar 

  6. Diaz LA, Calvanico NJ, Tomasi TB Jr (1977) Bullous pemphigoid antigen: isolation from normal human skin. J. Immunol 118: 455

    PubMed  CAS  Google Scholar 

  7. Dvorak HF, Mihm MC Jr (1972) Basophilic leukocytes in allergic contact dermatitis. J Exp Med 135: 235

    Article  PubMed  CAS  Google Scholar 

  8. Dvorak AM, Wintroub BU, Mihm MC Jr (1981) Bullous pemphigoid: a sequential ultrastructural study (submitted for publication)

    Google Scholar 

  9. Fearon DT (1978) Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway. Proc Natl Acad Sci USA 75: 1971

    Article  PubMed  CAS  Google Scholar 

  10. Fearon DT, Austen KF (1977) Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins. J Exp Med 146: 22

    Article  PubMed  CAS  Google Scholar 

  11. Goetzl EJ, Austen KF (1975) Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: identification as eosinophil chemotactic factor of anaphylaxis. Proc Natl Acad Sci USA 72: 4123

    Article  PubMed  CAS  Google Scholar 

  12. Hartmann KU, Bokisch VA (1975) Stimulation of murine B lymphocytes by isolated C3b. J Exp Med 142: 600

    Article  PubMed  CAS  Google Scholar 

  13. Hashimoto K, Lever WF (1976) An electron microscopic study of pemphigus vulgaris of the mouth and the skin with special reference to the intercellular cement. J Invest Dermatol 48: 540

    Google Scholar 

  14. Holubar K, Wolff K, Konrad K, Beutner EH (1975) Ultrastructure localization of immunoglobulins in bullous pemphigoid skin. J Invest Dermatol 64: 22

    Article  Google Scholar 

  15. Jordon RE, Beutner EH, Witebsky E, Blumental G, Hale WL, Lever WF (1967) Basement zone antibodies in bullous pemphigoid. JAMA 200:751

    Article  PubMed  CAS  Google Scholar 

  16. Jordon RE, Schroeter AL, Good RA, Day NK (1975) The complement system in bullous pemphigoid. II. Immunofluorescent evidence for both classical and alternate-pathway activation. Clin Immunol Immunopathol 3: 307

    Article  PubMed  CAS  Google Scholar 

  17. Kay AB, Austen KF (1971) The IgE-mediated release of an eosinophil chemotactic factor from human lung. J immunol 107: 899

    PubMed  CAS  Google Scholar 

  18. Lachmann PJ, Kay AB, Thompson RA (1970) The chemotactic activity for neutrophil and eosinophil leukocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the “reactive lysis” procedure. Immunology 19: 895

    PubMed  CAS  Google Scholar 

  19. Lepow IH, Willms-Kreschmer K, Patrick RA, Rosen FS (1970) Gross und ultrastructural observations on lesions produced by intradermal injection of human C3a in man. Am J Pathol 61:13

    PubMed  CAS  Google Scholar 

  20. Lever WF (1953) Pemphigus. Medicine 32: 1

    Article  PubMed  CAS  Google Scholar 

  21. Lever WF (1965) Pemphigus and phemphigoid. Thomas Springfield

    Google Scholar 

  22. Lever WF, Hashimoto K (1969) The etiology and treatment of pemphigus and pemphigoid. J Invest Dermatol 53: 373

    PubMed  CAS  Google Scholar 

  23. Provost TT, Tomasi TB Jr (1973) Evidence for complement activation via the alternate pathway in skin diseases. I. Herpes gestationis, systemic lupus erythematosus, and bullous pemphigoid. J Clin Invest 52: 1779

    CAS  Google Scholar 

  24. Sams WM Jr, Jordon RE (1971) Correlation of pemphigoid and pemphigus antibody titres with activity of disease. Br J Dermatol 84: 7

    Article  PubMed  Google Scholar 

  25. Schaumberg-Lever G, Rule A, Schmidt-Ullrich B, Lever WF (1975) Ultrastructure localization of in vivo bound immunoglobulins in bulleous pemphigoid. J Invest Dermatol 64: 47

    Article  Google Scholar 

  26. Schmidt-Ullrich B, Rule A, Schaumberg-Lever G, Leblanc C (1975) Ultrastructural localization of in vivo bound complement in bullous pemphigoid J Invest Dermatol 65: 217

    Article  PubMed  CAS  Google Scholar 

  27. Wilkinson PC, Roberts JA, Russel RJ, McLoughlin M (1976) Chemotaxis of mitogen-activated human lymphocytes and the effects of membrane-active enzymes. Clin Exp Immunol 25: 280

    PubMed  CAS  Google Scholar 

  28. Wintroub BU, Mihm MC Jr (Unpublished observations)

    Google Scholar 

  29. Wintroub BU, Mihm MC, Goetzl EJ, Soter NA, Austen KF (1978) Morphologic and functional evidence for release of mast cell products in bullous pemphigoid. N Engl J Med 298: 417

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Dermatology and Pathology, Harvard Medical School, 250 Longwood Avenue, Boston, MA, 02115, USA

    Bruce U. Wintroub

  2. Immunodermatology Section of the Department of Rheumatology and Immunology and Division of Dermatology of the Department of Medicine, Brigham and Women’s Hospital, 250 Longwood Avenue, Boston, MA, 02115, USA

    Bruce U. Wintroub

  3. Dermatology Service and James Homer Wright Laboratories of the Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

    Martin C. Mihm

Authors
  1. Bruce U. Wintroub
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  2. Martin C. Mihm
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Editor information

Editors and Affiliations

  1. Department of Dermatology, University of California, San Diego, University Hospital, 225 Bickinson Street, San Diego, CA, 92103, USA

    Irma N. Gigli

  2. Division d’Hématologie du Department de Médicine, Hôpital Cantonal, 25, rue Micheli-du Crest, CH-1211, Genève, Switzerland

    Peter A. Miescher

  3. Department of Molecular Immunology, Scripps Clinic and Research Foundation, 1066 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Hans J. Müller-Eberhard

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© 1983 Springer-Verlag Berlin Heidelberg

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Wintroub, B.U., Mihm, M.C. (1983). Mast Cell-Dependent Effector Pathways and Cutaneous Bullous Disorders. In: Gigli, I.N., Miescher, P.A., Müller-Eberhard, H.J. (eds) Immunodermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68702-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-68702-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11738-4

  • Online ISBN: 978-3-642-68702-0

  • eBook Packages: Springer Book Archive

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