Skip to main content
SpringerLink
Log in

Dermatitis Herpetiformis

  • Chapter
Immunodermatology

  • 44 Accesses

Abstract

In 1884, Louis Durhing detailed the clinical features of dermatitis herpetiformis (DH) [4]. Although the etiology is still unknown, considerable knowledge about DH has been attained over the past 15 years. Stimulated by the discoveries of Cormane [3] and Van der Meer [45] that IgA is deposited in the skin of these patients, and the discovery of Marks et al. [25] that there is an associated gastrointestinal abnormality, intense investigation has been undertaken to determine the roles of the immune system and the gastrointestinal lesion in the pathogenesis of DH. In this review we will describe these findings and other more recent advances and draw from them conclusions as to possible pathophysiologic mechanisms which may be involved in DH.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brow JR, Parker F, Weinstein WM, Rubin CE (1971) The small intestinal mucosa in dermatitis herpetiformis. Gastroenterology 60: 355

    PubMed  CAS  Google Scholar 

  2. Chorzelski TP, Beutner EH, Jablonska A, Blaszczyk M, Triftshauser C (1971) Immunofluorescent studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid. J Invest Dermatol 56: 373

    Article  PubMed  CAS  Google Scholar 

  3. Cormane RH (1967) Immunofluorescent studies of the skin in lupus erythematosus and other diseases. Pathologia Europ 2: 170

    Google Scholar 

  4. Duhring L (1884) Dermatitis herpetiformis. JAMA 3: 225

    Google Scholar 

  5. Falchuk ZM, Rogentine GN, Strober W (1973) Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest 51: 1602

    Article  Google Scholar 

  6. Fry L, Seah PP (1974) Dermatitis herpetiformis In: Fry L, Seah PP (eds) Immunological aspects of skin disease. Wiley, New York, p 22

    Google Scholar 

  7. Fry L, Keir P, McMinn RMH, Cowan JD, Hoffbrand AV (1967) Small intestinal structure and function and hematological changes in dermatitis herpetiformis. Lancet ii: 729

    Article  Google Scholar 

  8. Fry L, McMinn RMH, Cowan J, Hoffbrand AV (1968) Effect of gluten-free diet on dermatological, intestinal and haematological manifestations of dermatitis herpetiformis. Lancet i: 557

    Article  Google Scholar 

  9. Fry L, Seah PP, Riches DJ, Hoffbrand AV (1973) Clearance of skin lesions in dermatitis herpetiformis after gluten withdrawal. Lancet i: 288

    Article  Google Scholar 

  10. Fry L, Walkden V, Wojnarowska F, Haffenden G, McMinn RMH (1980) A comparison of IgA positive and IgA negative dapsone responsive dermatoses. Br J Dermatol 102: 371

    Article  PubMed  CAS  Google Scholar 

  11. Gebhard RL, Katz SI, Marks J, Shuster S, Trapani RJ, Rogentine GN, Strober W (1973) HL-A antigen type and small intestinal disease in dermatitis herpetiformis. Lancet ii: 760

    Article  Google Scholar 

  12. Gebhard RL, Falchuk ZM, Katz SI, Sessoms C, Rogentine GN, Strober W (1974) Dermatitis herpetiformis, immunologic concomitants of small intestinal disease and relationships to histocompatibility antigen HLA8. J Clin Invest 54: 98

    Article  PubMed  CAS  Google Scholar 

  13. Haffenden G, Wojnarowska F, Fry L (1974) Comparison of immunoglobulin and complement deposition in multiple biopsies from the uninvolved skin in dermatitis herpetiformis. Br J Dermatol 101: 39

    Article  Google Scholar 

  14. Hall RP, Lawley TJ, Heck JA, Katz SI (1980) IgA containing immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus, and other diseases. Clin Exp Immunol 40: 431

    PubMed  CAS  Google Scholar 

  15. Katz SI, Lawley TJ (1979) Dermatitis herpetiformis In: Beutner EH (ed) Recent advances in immunopathology of the skin. J Wiley, New York, p 303

    Google Scholar 

  16. Katz SI, Strober W (1978) The pathogenesis of dermatitis herpetiformis. J Invest Dermatol 70: 63

    Article  PubMed  CAS  Google Scholar 

  17. Katz SI, Falchuk ZM, Dahl MV, Rogentine GM, Strober W (1972) HL-A8: A genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy. J Clin Invest 51: 2977

    Article  PubMed  CAS  Google Scholar 

  18. Katz SI, Hertz KC, Crawford PS, Gazze LA, Frank M, Lawley TJ (1976) Effect of sulfones on complement deposition in dermatitis herpetiformis and on complement-mediated guinea pig reactions. J Invest Dermatol 67: 688

    Article  PubMed  CAS  Google Scholar 

  19. Katz SI, Hertz KC, Rogentine GN, Strober W (1977) HLA-B8 and dermatitis herpetiformis in patients with IgA depostis in skin. Arch Dermatol 113: 155

    Article  PubMed  CAS  Google Scholar 

  20. Katz SI, Hall RP, Lawley TJ, Strober W (1980) Dermatitis herpetiformis: the skin and the gut. Ann Intern Med 93: 857

    PubMed  CAS  Google Scholar 

  21. Keuning JJ, Pena AS, van Leeuwen A, van Hooff JP, van Rood JJ (1976) HLA-Dw3 associated with coeliac disease. Lancet i: 506

    Article  Google Scholar 

  22. Lang PG (1979) Sulfone and sulfonamides in dermatology today. J Am Acad Dermatol 1: 479

    Article  PubMed  Google Scholar 

  23. Lawley TJ, Strober W, Yaoita H, Katz SI (1980) Small intestinal biopsies and HLA types in dermatitis herpetiformis patients with granular and linear IgA skin deposits. J Invest Dermatol 74:9

    Article  PubMed  CAS  Google Scholar 

  24. Mann DL, Katz SI, Nelson DL, Abelson LD, Strober W (1976) Specific B-cell antigens associated with gluten-sensitive enteropathy and dermatitis herpetiformi Lancet i: 110

    Article  Google Scholar 

  25. Marks J, Shuster S, Watson AJ (1966) Small bowel changes in dermatitis herpetiformis. Lancet ii: 1280

    Article  Google Scholar 

  26. Marks J, Birkett D, Shuster S, Robert DF (1970) Small intestinal mucosal abnormalities in relatives of patients with dermatitis herpetiformis. Gut 11: 493

    Article  PubMed  CAS  Google Scholar 

  27. Mohammed I, Holborow EJ, Fry L, Thompson BR (1976) Multiple immune complexes and hypocomplementaemia in dermatitis herpetiformis and coeliac disease. Lancet ii: 487

    Article  Google Scholar 

  28. Mowbray JF, Hoffbrand AV, Holborow EJ, Seah PP, Fry L (1973) Circulating immune complexes in dermatitis herpetiformis. Lancet i: 400

    Article  Google Scholar 

  29. Pehamberger H, Konrad K, Holubar K (1977) Circulating IgA anti-basement membrane antibodies in linear dermatitis herpetiformis (Duhring): Immunofluroescence and immunoelectron microscopic studies. J Invest Dermatol 69: 490

    Article  PubMed  CAS  Google Scholar 

  30. Pehamberger H, Gschnait F, Menzel J, Holubar K (1979) Failure to detect gliadin or gliadin-binding sites in the skin of patients with dermatitis herpetiformis: Immunofluorescence, organ culture and autoradiographic studies. J Invest Dermatol 73: 174

    Article  PubMed  CAS  Google Scholar 

  31. Pena AS, Mann DL, Hague NE, Heck JA, van Leeuwen A, van Rood JJ, Stedber, W (1978) Genetic basis of gluten-sensitive enteropathy. Gastroenterology 75: 230

    PubMed  CAS  Google Scholar 

  32. Provost TT, Tomasi TB (1974) Evidence for the activation of complement via the alternate pathway in skin diseases. II. Dermatitis herpetiformis. Clin Immunol Immunopathol 3: 178

    Article  CAS  Google Scholar 

  33. Reunala T (1978) Gluten-free diet in dermatitis herpetiformis. II Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls. Br J Dermatol 98: 69

    CAS  Google Scholar 

  34. Reunala T, Salo OP, Tiilikainen A, Mattila MJ (1976) Histocompatibility antigens and dermatitis herpetiformis with special reference to jejunal abnormalities and acetylator phenotype. Br J Dermatol 94: 138

    Article  Google Scholar 

  35. Reunala T, Salo OP, Tiilikainen A, Selroos O, Kuitunen P (1976) Family studies in dermatitis herpetiformis. Ann Clin Res 8: 254

    PubMed  CAS  Google Scholar 

  36. Scott BB, Losowsky MS (1975) Patchiness and mucosal abnormality in coeliac disease (CD) and dermatitis herpetiformis. Gut 16: 393

    Article  PubMed  CAS  Google Scholar 

  37. Seah PP, Fry L, Hoffbrand AV, Holborow EJ (1971) Tissue antibodies in dermatitis herpetiformis and adult coeliac disease. Lancet i: 834

    Article  Google Scholar 

  38. Seah PP, Mazaheri MR, Fry L (1973) Complement in the skin of patients with dermatitis herpetiformis. Br J Dermatol 89 (suppl): 12

    Article  Google Scholar 

  39. Seah PP, Fry L, Kearney JW, Campbell E, Mowbray JF, Stewart JS, Hoffbrand AV (1976) A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease. Br J Dermatol 94: 133

    Article  Google Scholar 

  40. Shuister S, Watson AJ, Marks J (1968) Coeliac syndrome in dermatitis herpetiformis. Lancet i: 1101

    Article  Google Scholar 

  41. Solheim BG, Ek J, Thune PO, Baklein K, Bratlir A, Rankin B, Thoresen AB, Thorsby E (1976) HLA antigens in dermatitis herpetiormis and coeliac disease. Tissue Antigens 7: 57

    Article  PubMed  CAS  Google Scholar 

  42. Stingl G, Hönigsmann H, Holubar K, Wolff K (1976) Ultrastructural localization of immunoglobulins in dermatitis herpetiformis. J Invest Dermatol 67: 507

    Article  PubMed  CAS  Google Scholar 

  43. Stokes PL, Asquith P, Holmes GKT, MacKintosh P, Cooke WT (1972) Histocompatibility antigens associated with adult coeliac disease. Lancet ii: 162

    Article  Google Scholar 

  44. Thomsen M, Platz P, Marks J, Ryder LP, Shuster S, Svejgaard A, Young SH (1976) Association of LD-8a and LD-12a with dermatitis herpetiformis. Tissue Antigens 7: 60

    Article  PubMed  CAS  Google Scholar 

  45. Van der Meer JB (1969) Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis. An immunofluorescent study. Br J Dermatol 1: 493

    Article  Google Scholar 

  46. Van der Meer JB (1972) Dermatitis herpetiformis: A specific (immunopathologic) Entity, Utrecht University the Netherlands, Thesis, p 88

    Google Scholar 

  47. Weinstein WM (1974) Latent celiac sprue. Gastroenterology 66: 489

    PubMed  CAS  Google Scholar 

  48. White AG, Barnetson RS, Costa JAG, McClelland DBL (1973) The incidence of HL-A antigens in dermatitis herpetiformis. Br J Dermatol 89: 133

    Article  PubMed  CAS  Google Scholar 

  49. Yaoita H (1978) Identification of IgA binding structures in skin of patients with dermatitis herpetiformis. J Invest Dermatol 71: 213

    Article  PubMed  CAS  Google Scholar 

  50. Yaoita H, Katz SI (1976) Immunoelectronmicroscopic localization of IgA in skin of patients with dermatitis herpetiformis. J Invest Dermatol 67: 502

    Article  PubMed  CAS  Google Scholar 

  51. Yaoita H, Katz SI (1977) Circulating IgA anti-basement membrane zone antibodies in dermatitis herpetiformis. J Invest Dermatol 69: 558

    Article  PubMed  CAS  Google Scholar 

  52. Zone JJ, LaSalle BA, Provost TT (1980) Circulating immune complexes of IgA type in dermatitis herpetiformis, J Invest Dermatol 75: 152

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dermatology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Room 12N238, Bethesda, Maryland, 20205, USA

    Russell P. Hall, Thomas J. Lawley & Stephen I. Katz

Authors
  1. Russell P. Hall
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas J. Lawley
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen I. Katz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of California, San Diego, University Hospital, 225 Bickinson Street, San Diego, CA, 92103, USA

    Irma N. Gigli

  2. Division d’Hématologie du Department de Médicine, Hôpital Cantonal, 25, rue Micheli-du Crest, CH-1211, Genève, Switzerland

    Peter A. Miescher

  3. Department of Molecular Immunology, Scripps Clinic and Research Foundation, 1066 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Hans J. Müller-Eberhard

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hall, R.P., Lawley, T.J., Katz, S.I. (1983). Dermatitis Herpetiformis. In: Gigli, I.N., Miescher, P.A., Müller-Eberhard, H.J. (eds) Immunodermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68702-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68702-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11738-4

  • Online ISBN: 978-3-642-68702-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation