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Antibody-Induced Proteinase Activation: A Proposed Mechanism for Pemphigus

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Immunodermatology

Abstract

Pemphigus is a severe, blistering disease of the skin and mucous membranes which is characterized by the presence of an autoantibody directed against the surface of epidermal cells [43,45]. There are several types of pemphigus which are distinguished by their clinical presentations, histopathology, and immunopathologic findings [37].

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Author information

Authors and Affiliations

  1. Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Kay Hiemstra Singer, Koji Hashimoto & Gerald S. Lazarus

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  1. Kay Hiemstra Singer
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  2. Koji Hashimoto
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  3. Gerald S. Lazarus
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Editor information

Editors and Affiliations

  1. Department of Dermatology, University of California, San Diego, University Hospital, 225 Bickinson Street, San Diego, CA, 92103, USA

    Irma N. Gigli

  2. Division d’Hématologie du Department de Médicine, Hôpital Cantonal, 25, rue Micheli-du Crest, CH-1211, Genève, Switzerland

    Peter A. Miescher

  3. Department of Molecular Immunology, Scripps Clinic and Research Foundation, 1066 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Hans J. Müller-Eberhard

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© 1983 Springer-Verlag Berlin Heidelberg

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Singer, K.H., Hashimoto, K., Lazarus, G.S. (1983). Antibody-Induced Proteinase Activation: A Proposed Mechanism for Pemphigus. In: Gigli, I.N., Miescher, P.A., Müller-Eberhard, H.J. (eds) Immunodermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68702-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-68702-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11738-4

  • Online ISBN: 978-3-642-68702-0

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