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Effect of Cephalothin and Gentamicin on Phagocytosis of Klebsiella pneumoniae by Guinea Pig Alveolar Macrophages

  • Conference paper
The Influence of Antibiotics on the Host-Parasite Relationship

Abstract

It has been well established that bacterial clearance from the lung depends almost entirely on phagocytosis by the alveolar macrophage because these cells represent the first line of defense against inhaled pathogens [10, 12]. Once pulmonary inflammatory disease has developed, antimicrobial chemotherapy is started to destroy the etiologic agent and thereby to support the removal of the bacteria by the immune system of the host. Since the invention of chemotherapy, the direct effect of the antimicrobial substance on the bacteria and the pharmacokinetics have been studied extensively, while host defense mechanisms during chemotherapy have attracted far less attention.

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Author information

Authors and Affiliations

  1. Bayer Pharma Research Centre, Institute for Chemotherapy, 5600, Wuppertal, Germany

    H. Brunner

  2. Institute for Medical Microbiology, University of Düsseldorf, Germany

    C. Undeutsch

Authors
  1. H. Brunner
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  2. C. Undeutsch
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Editor information

Editors and Affiliations

  1. Chefarzt der Urologischen Klinik, St. Franziskus-Hospital, Kiskerstraße 26, 4800, Bielefeld 1, Germany

    Hans-Udo Eickenberg F.A.C.S.

  2. Institut für Medizinische Mikrobiologie, Freie Universität Berlin, Hindenburgdamm 27, 1000, Berlin 45, Germany

    Helmut Hahn

  3. Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Ruhr-Universität Bochum, Postfach 102148, 4630, Bochum, Germany

    Wolfgang Opferkuch

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© 1982 Springer-Verlag

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Brunner, H., Undeutsch, C. (1982). Effect of Cephalothin and Gentamicin on Phagocytosis of Klebsiella pneumoniae by Guinea Pig Alveolar Macrophages. In: Eickenberg, HU., Hahn, H., Opferkuch, W. (eds) The Influence of Antibiotics on the Host-Parasite Relationship. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68670-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-68670-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11680-6

  • Online ISBN: 978-3-642-68670-2

  • eBook Packages: Springer Book Archive

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