Effect of Cephalothin and Gentamicin on Phagocytosis of Klebsiella pneumoniae by Guinea Pig Alveolar Macrophages

  • H. Brunner
  • C. Undeutsch


It has been well established that bacterial clearance from the lung depends almost entirely on phagocytosis by the alveolar macrophage because these cells represent the first line of defense against inhaled pathogens [10, 12]. Once pulmonary inflammatory disease has developed, antimicrobial chemotherapy is started to destroy the etiologic agent and thereby to support the removal of the bacteria by the immune system of the host. Since the invention of chemotherapy, the direct effect of the antimicrobial substance on the bacteria and the pharmacokinetics have been studied extensively, while host defense mechanisms during chemotherapy have attracted far less attention.


Minimal Inhibitory Concentration Colony Form Unit Alveolar Macrophage Klebsiella Pneumoniae Minimal Bactericidal Concentration 
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • H. Brunner
    • 1
  • C. Undeutsch
    • 2
  1. 1.Bayer Pharma Research CentreInstitute for ChemotherapyWuppertalGermany
  2. 2.Institute for Medical MicrobiologyUniversity of DüsseldorfGermany

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