Focal Neurological Lesions and Diffuse Organic Brain Damage in Open-Heart Surgery Patients

Postoperative Thrombocytosis and Platelet Aggregation — A Possible Aetiological Factor in the Causation of Organic Brain Dysfunction
  • D. W. Bethune


Neuropsychiatric dysfunction occurring after open-heart surgery is usually considered to be related to intraoperative events.

A case history is presented which suggests that marked changes in neuropsychiatric function can occur in the immediate postoperative period with a history and time course which is incompatible with a direct intraoperative cause. The evidence from psychometric testing indicated a disturbance of delayed memory recall which would suggest an organic basis for the symptoms. Analysis of the records of a group of patients who were studied in detail with pre- and postoperative interviewing, identified a significant incidence of changes suggestive of organic neuropsychiatrie dysfunction occurring remote from the immediate operative period.


Coronary Artery Bypass Grafting Ventricular Aneurysm Bubble Oxygenator Coronary Artery Graft Cardiotomy Suction 
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  1. 1.
    Preston FE, Martin JF, Stewart RM, Davies-Jones GAB (1979) Thrombocytosis, circulating platelet aggregates and neurological dysfunction. Br Med J 2:1561PubMedCrossRefGoogle Scholar
  2. 2.
    Branthwaite MA (1972) Neurological damage related to open-heart surgery. A clinical survey. Thorax 27:748PubMedCrossRefGoogle Scholar
  3. 3.
    Branthwaite MA (1973) Detection of neurological damage during open-heart surgery. Thorax 28:464PubMedCrossRefGoogle Scholar
  4. 4.
    Heller SS, Frank KH, Malm JR, et al. (1970) Psychiatric complications to open-heart surgery. N Engl J Med 283:1015PubMedCrossRefGoogle Scholar
  5. 5.
    William M (1953) Investigation of amnesic defects by progressive prompting. J Neurol Neuro-surg Psychiatry 16:14CrossRefGoogle Scholar
  6. 6.
    Bethune DW (to be published) Test of delayed memory recall suitable for assessing postoperative amnesia. Anaesthesia 35Google Scholar
  7. 7.
    Bethune DW (1980) The assessment of organic brain damage following open-heart surgery. In: Speidel H, Rodewald G (eds) Psychic and neurological dysfunctions after open-heart surgery. INA 19:100–106 Thieme, StuttgartGoogle Scholar
  8. 8.
    Dubin WR, Field HL, Gastfriend DR (1979) Post cardiotomy delirium: A critical review. J Thorac Cardiovasc Surg 77:586PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1982

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  • D. W. Bethune

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