Skip to main content
SpringerLink
Log in

Endogenous Catecholamines Under Chronic Vasodilator Treatment

  • Chapter
Vasodilators in Chronic Heart Failure

  • 58 Accesses

Abstract

Today there is abundant evidence that sympathetic activity is enhanced in cardiac failure (7, 8, 11, 14, 34). The increased plasma concentration of the endogenous neurotransmitter noradrenaline augments heart rate and contractility of the failing heart. Since the cardiac muscle fibers are hypersensitive to endogenous or exogenous catecholamines in heart failure, these hormones seem to be essential in restoring left ventricular function. However, the elevated plasma level of noradrenaline, together with an activation of the renin-angiotensin-aldosterone system leads to an increased stiffness of the arteriolar wall due to salt and water retention. This results in an elevation of peripheral resistance to restore an adaequate perfusion pressure of the vital organs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aronow WS, Donahy DT (1978) Efficacy of trimazosin and prazosin therapy on cardiac and exercise performance in outpatients with chronic congestive heart failure. Am J Med 65: 155

    Article  PubMed  CAS  Google Scholar 

  2. Aronow WS, Lurie M, Turbow M, Whittakter K, Van Camp S, Hughes D (1979) Effect of prazosin vs placebo on chronic left ventricular heart failure. Circulation 59: 344

    PubMed  CAS  Google Scholar 

  3. Awan NA, Miller RR, Miller MP, Specht K, Vera Z, Mason DT (1978) Clinical pharmacology and therapeutic application of prazosin in acute and chronic refractory congestive heart failure. Am J Med 65: 146

    Article  PubMed  CAS  Google Scholar 

  4. Cavern I, Fenard S, Gomeni R et al. (1978) Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits. Eur J Pharmacol 49: 259

    Article  Google Scholar 

  5. Chatterjee K, Parmley WW, Massie B, Greenberg B, Werner J, Klausner S, Norman A (1976) Oral hydralazin therapy for chronic refractory heart failure. Circulation 54: 879

    PubMed  CAS  Google Scholar 

  6. Chatterjee K, Parmley WW (1977) The role of vasodilator therapy in heart failure. Prog Cardiovasc Dis 19: 301

    Article  PubMed  CAS  Google Scholar 

  7. Chidsey CA, Harrison DC, Braunwald E (1962) Augmentation of the plasma norepinephrine response to exercise in patients with congestive heart failure. N Engl J Med 267: 650

    Article  PubMed  CAS  Google Scholar 

  8. Chidsey CA, Braunwald E, Morov AG et al. (1963) Myocardial norepinephrine concentration in man: effects of reserpine and of congestive heart failure. N Engl J Med 269: 653

    Article  PubMed  CAS  Google Scholar 

  9. Cohn IN (1973) Vasodilator therapy for heart failure. Circulation 48: 5

    PubMed  CAS  Google Scholar 

  10. Cohn JN, Taylor N, Vrobel T, Moskowitz R (1978) Contrasting effect of vasodilators on heart rate and plasma catecholamines in patients with hypertension and heart failure. Clin Res 26:547 A

    Google Scholar 

  11. Curtis C, Cohn JN, Vrobel T, Franciosa JA (1978) Role of the renin-angiotensin system in the systemic vasoconstriction of chronic heart failure. Circulation 58: 763

    Google Scholar 

  12. Fahmy NR, Sunder N, Moss J et al. (1979) Tachyphylaxis to nitroprusside. Role of the reninangiotensin system and catecholamines in its development. Anesthesiology [Suppl] 51: 72

    Google Scholar 

  13. Franciosa JA, Blank RC, Cohn JN (1978) Nitrate effects on cardiac output and left ventricular outflow resistance in chronic congestive heart failure. Am J Med 64: 207

    Article  PubMed  CAS  Google Scholar 

  14. Francis GS, Goldsmith SR, Cohn IN (1981) The sympathetic response to exercise in patients with congestive heart failure. Am J Cardiol 47: 395

    Article  Google Scholar 

  15. Graham RM, Pettinger WA (1979) Prazosin. N Engl J Med 300: 232

    Article  CAS  Google Scholar 

  16. Graham RM, Kennedy P, Stephenson W, Pettinger WA (1978) In vivo evidence for the pre-synaptic a-adrenergic receptor controlling norepinephrine release. Fed Proc 37: 308

    Google Scholar 

  17. Himmler FC, Wirtzfeld A, Klein G, Volger E, Schmidt G (1980) Hämodynamische Wirkung von Prazosin bei Patienten mit schwerer Herzinsuffizienz. Herz/Kreisl 12: 317

    Google Scholar 

  18. Imhof P (1977) Behandlung der Herzinsuffizienz mit Phentolamin. Schweiz Med Wochenschr 107: 1041

    PubMed  CAS  Google Scholar 

  19. Kersting F, Samosny G, Kasper W, Meinertz T, Gilfrich H-J, Just H (1980) Clinical pharmacology of prazosin and phentolamine in patients with heart failure. J Cardiovasc Pharmacol 2: 373

    Google Scholar 

  20. Klein W, Brandt D, Harpf H, Goebel R (1979) Fortschritte in der Therapie der akuten und chronischen Herzinsuffizienz durch den Einsatz systemischer Vasodilatatoren. Wien Med Wochenschr 129: 625

    PubMed  CAS  Google Scholar 

  21. Klein W, Goebel R (1980) Hämodynamik und Katecholaminstoffwechsel unter einer Vasodilatatorentherapie der chronischen Linksinsuffizienz. Z Kardiol 69: 120

    PubMed  CAS  Google Scholar 

  22. Klein W, Goebel R, Brandt D, Maurer E (1981) Effect of nitroglycerin on hemodynamics and catecholamines in patients with left heart failure. In: Engel/Lichtlen (eds) Nitrates IV. Springer, Berlin Heidelberg New York, p 244

    Google Scholar 

  23. Koch G (1979) Combined beta-receptor and calcium blockade in ischemic heart disease: effect on hemodynamics and plasma catecholamines (Abstr). 4th International AdalatSymposium, Paris, 1979

    Google Scholar 

  24. De Leeuw PW, Wester A, Willemse PJ, Birkenhäger WH (1980) Effects of prazosin on plasma noradrenaline and plasma renin concentrations in hypertensive subjects. J Cardiovasc Pharmacol 2: 361

    Google Scholar 

  25. Lichtlen P (1975) Die Wirkung von Nitriten und Nitraten auf die linksventrikuläre und koronare Dynamik in Ruhe und während dynamischer Belastung. In: Rudolph W et al. (ed) Nitrate-Wirkung auf Herz und Kreislauf. Urban & Schwarzenberg, Baltimore Munich, p 80

    Google Scholar 

  26. Manthey J (1981) Effect of vasodilator therapy on sympathetic activity in patients with impaired left ventricular function (Abstr). International Symposium “Catecholamines and the Heart”, München, 1981

    Google Scholar 

  27. Maskowski AH, Nicholls MG, Ikram H, Espiner EA (1981) Haemodynamic hormonal and electrolyte responses to captopril in resistant heart failure. Lancet 71

    Google Scholar 

  28. Mason DT (1978) Ventricular afterload reduction in management of congestive heart failure: a rational new concept that has rapidly come of age by vasodilator drugs. Clin Cardiol 1: 55

    PubMed  CAS  Google Scholar 

  29. Miller RR, Awan NA, Maxwell KS, Mason DT (1977) Sustained reduction of cardiac impedance and preload in congestive heart failure with the antihypertensive vasodilator prazosin. N Engl J Med 297: 303

    Article  PubMed  CAS  Google Scholar 

  30. Muiesan E, Agabiti-Rosei E, Alicandri C, Beschi M, Castellano M, Pasini C, Platto L (1980) Influence of verapamil on catecholamines, renin and aldosterone in hypertensive patients (Abstr). International Symposium Calcium Antagonism in Cardiovascular Therapy, Florenz, 1980

    Google Scholar 

  31. Muiesan E (1980) Diskussionsbemerkung zu 24. J Cardiovasc Pharmacol (Suppl 31 2: 368

    Google Scholar 

  32. Packer M, Meller J (1978) Oral vasodilator therapy for chronic heart failure: a plea for caution. Am J Cardiol 42: 686

    Article  PubMed  CAS  Google Scholar 

  33. Da Prada M, Zurcher G (1976) Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci 19: 1161

    Article  PubMed  Google Scholar 

  34. Thomas JA, Marks BH (1978) Plasma norepinephrine in congestive heart failure. Am J Cardiol 41: 233

    Article  PubMed  CAS  Google Scholar 

  35. Williams DD, Bommer WJ, Miller RR, Amsterdam EA, Mason DT (1977) Hemodynamic assessment of oral peripheral vasodilator therapy in chronic congestive heart failure: prolonged effectiveness of isosorbide dinitrate. Am J Cardiol 39: 84

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kardiologie, Medizinische Klinik III, Hugstetter Str. 55, 7800, Freiburg im Breisgau, Germany

    H. Just

  2. Zentrum der Inneren Medizin Abteilung für Kardiologie, Klinikum der J.-W.-Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankfurt/Main 70, Germany

    W.-D. Bussmann

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Klein, W. (1983). Endogenous Catecholamines Under Chronic Vasodilator Treatment. In: Just, H., Bussmann, WD. (eds) Vasodilators in Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68605-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68605-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68607-8

  • Online ISBN: 978-3-642-68605-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation