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Efficacy of AR-L 115 BS on Hemodynamics, Contractility, and Myocardial Oxygen Consumption in Man

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Book cover Vasodilators in Chronic Heart Failure

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Abstract

In search of new drugs with positive isotropic and vasodilatory effects for treating chronic congestive heart failure, the imidazole derivative AR-L 115 BS (2-[(2-methoxy-4-methylsulfinyl)-phenyl]-1H-imidazo [4, 5-b]pyridine) was developed. It combines the following effects: high direct cardiac efficacy, a distinctly higher therapeutic range than digitalis glycosides, no substantial increase in the heart rate, long biological half life, and good intestinal reabsorption.

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Authors
  1. M. Oeff
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  2. R. Schröder
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Editor information

Editors and Affiliations

  1. Kardiologie, Medizinische Klinik III, Hugstetter Str. 55, 7800, Freiburg im Breisgau, Germany

    H. Just

  2. Zentrum der Inneren Medizin Abteilung für Kardiologie, Klinikum der J.-W.-Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankfurt/Main 70, Germany

    W.-D. Bussmann

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© 1983 Springer-Verlag Berlin Heidelberg

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Oeff, M., Schröder, R. (1983). Efficacy of AR-L 115 BS on Hemodynamics, Contractility, and Myocardial Oxygen Consumption in Man. In: Just, H., Bussmann, WD. (eds) Vasodilators in Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68605-4_23

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  • DOI: https://doi.org/10.1007/978-3-642-68605-4_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68607-8

  • Online ISBN: 978-3-642-68605-4

  • eBook Packages: Springer Book Archive

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