Human T Cell Hybridomas with Tetanus-Toxoid-Specific Helper Activity

  • E. C. DeFreitas
  • S. Vella
  • A. Linnenbach
  • C. M. Croce
  • H. Koprowski
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)


Somatic cell hybridization first described by Barski et al. (1) initiated an era in cell biology wherein differential genetic and functional properties could be expressed and regulated in the same cell. This approach was utilized by Milstein and Kohler (2) to combine the properties of specific antibody secretion and continuous growth in vitro when they successfully fused normal mouse B lymphocytes with enzyme-deficient mouse myeloma cells.


Peripheral Blood Lymphocyte Tetanus Toxoid Helper Activity Normal Peripheral Blood Specific Antibody Production 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • E. C. DeFreitas
  • S. Vella
  • A. Linnenbach
  • C. M. Croce
  • H. Koprowski

There are no affiliations available

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