A “Panreactive” T Cell Hybridoma Which Produces TCGF Constitutively

  • C. Corbel
  • J. Andersson
  • F. Melchers
  • J. Zeuthen
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)


We have isolated a T cell line which shows reactivities with irradiated spleen cells of any H-2 haplotype, including self. This “panreactive” T cell line was fused to EL4 and the stable “panreactive” T hybridoma E-M-19-I-1 was shown to help in a “bystander” antibody response to sheep red blood cells (SRC) (1). This “panreactivity” is shown in this paper to be useful as it induces “constitutive” TCGF production in mixtures as well as in fusions with a TCGF-production-inducible T cell hybridoma, BIII/4 (2).


Spleen Cell Preceding Article CTLL Cell Thymic Lymphoma Constitutive Production 
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  1. 1.
    Andersson, J, Melchers, F, Zeuthen, J (1982) A “Panreactive” T cell line and T cell hybridoma: Their function in helping B cells. (This volume.)Google Scholar
  2. 2.
    Gronvik, K-O, Andersson, J, Melchers, F, Zeuthen, J (1982) A stable TCGF-producing T cell hybridoma and its thioguanine-resistant variant suitable as a tool for the construction of new functional T hybridomas. (This volume.)Google Scholar
  3. 3.
    Stull, D, Gillis, S (1981) Constitutive production of interleukin-2 activity by a T cell hybridoma. J Immunol 126: 1680–1683PubMedGoogle Scholar
  4. 4.
    Melchers, F, Zeuthen, J, Gerhard, W (1982) Influenza virus-specific murine T cell hybridgifias which recognize virus hemagglutinin in conjunction with H-2 and display helper functions for B cells. (This volume.)Google Scholar
  5. 5.
    Rosenthal, AS, Schevach, EM (1973) Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirements for histocompatible macrophages and lymphocytes. J Exp Med 138: 1194–1212PubMedCrossRefGoogle Scholar
  6. 6.
    Sprent, J (1978) Role of H-2 gene products in the function of T helper cells from normal and chimeric mice in vivo. Immunol Rev 42: 108–148PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • C. Corbel
  • J. Andersson
  • F. Melchers
  • J. Zeuthen

There are no affiliations available

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