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A “Panreactive” T Cell Line and T Cell Hybridoma: Their Function in Helping B Cells

  • J. Andersson
  • F. Melchers
  • J. Zeuthen
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)

Abstract

Alloreactive T cells with specificities for Ia antigens encoded by the I-A locus of the major histocompatibility complex of the mouse are known as potent inducers of macrophages and B cells which express the corresponding Ia antigens. This induction in the presence of a “bystander” antigen, such as sheep erythrocytes (SRC), leads to the induction of “bystander” SRC-specific B cell responses (1,2). Self-antigens have also been found to act as such “bystanders”, inducing autoantibody production in the corresponding B cells of the reacting host (3). Such interactions of allo-Ia-reactive T cells also lead to the production of soluble mediators which can replace these T cells in their interactions with macrophages and B cells. These mediators were originally called allogeneic effect factors (AEF) (4,5). It was shown that AEF is composed of at least two separable groups of factors: those which specifically recognize Ia antigens on macrophages and B cells (5) and others which act on activated B cells as factors stimulating successive rounds of division and effecting increased maturation to Ig secretion.

Keywords

Spleen Cell Velocity Sedimentation Sheep Erythrocyte Helper Activity Helper Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • J. Andersson
  • F. Melchers
  • J. Zeuthen

There are no affiliations available

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