A Stable TCGF-Producing T Cell Hybridoma and its Thioguanine-Resistant Variant Suitable as a Tool for the Construction of New Functional T Hybridomas

  • K.-O. Grönvik
  • J. Andersson
  • F. Melchers
  • J. Zeuthen
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)


Recent studies have shown that antigens and mitogenic lectins initiate the activation of T cells. Proliferation of these activated cells, however, is dependent on T cell growth factors (TCGF or IL-2) (1–5). TCJF production requires a non-killer Ly 1+ T cell cooperating with la adherent cells under the influence of lectin or antigen (5–8). As most convincingly demonstrated with cloned helper T cells, TCGF production is the result of specific antigen recognition by the T cells in the context of histocompatibility antigens presented by viable adherent, macrophage-like cells (9,10).


Spleen Cell Phorbol Myristate Acetate CTLL Cell Immune Interferon Mitogenic Lectin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • K.-O. Grönvik
  • J. Andersson
  • F. Melchers
  • J. Zeuthen

There are no affiliations available

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