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A Stable TCGF-Producing T Cell Hybridoma and its Thioguanine-Resistant Variant Suitable as a Tool for the Construction of New Functional T Hybridomas

  • K.-O. Grönvik
  • J. Andersson
  • F. Melchers
  • J. Zeuthen
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)

Abstract

Recent studies have shown that antigens and mitogenic lectins initiate the activation of T cells. Proliferation of these activated cells, however, is dependent on T cell growth factors (TCGF or IL-2) (1–5). TCJF production requires a non-killer Ly 1+ T cell cooperating with la adherent cells under the influence of lectin or antigen (5–8). As most convincingly demonstrated with cloned helper T cells, TCGF production is the result of specific antigen recognition by the T cells in the context of histocompatibility antigens presented by viable adherent, macrophage-like cells (9,10).

Keywords

Spleen Cell Phorbol Myristate Acetate CTLL Cell Immune Interferon Mitogenic Lectin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • K.-O. Grönvik
  • J. Andersson
  • F. Melchers
  • J. Zeuthen

There are no affiliations available

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