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The Effect of Antigen Presentation on the Fine Specificity of Anti-Cytochrome c T Cell Hybridomas

  • E. Heber-Katz
  • D. Hansburg
  • R. H. Schwartz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)

Abstract

An important criterion for the use of T cell hybridomas in the study of immune responses or as a source for antigen receptors or cell recognition structures is the ability to clearly demonstrate normal immune response parameters. In studying the T cell response to cytochrome c, we have been able to show that the fine specificity of cytochrome c specific T cell hybrids resembles the response of normal T cells to this antigen. Furthermore, by holding the T cell constant we have been able to study the interaction of antigen-Ia-T cell in a way which has revealed some interesting results dealing with T cell activation and Ir gene defects.

Keywords

Spleen Cell Cell Hybrid Fine Specificity Cyanogen Bromide Costar Plate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • E. Heber-Katz
  • D. Hansburg
  • R. H. Schwartz

There are no affiliations available

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