The Effect of Antigen Presentation on the Fine Specificity of Anti-Cytochrome c T Cell Hybridomas
An important criterion for the use of T cell hybridomas in the study of immune responses or as a source for antigen receptors or cell recognition structures is the ability to clearly demonstrate normal immune response parameters. In studying the T cell response to cytochrome c, we have been able to show that the fine specificity of cytochrome c specific T cell hybrids resembles the response of normal T cells to this antigen. Furthermore, by holding the T cell constant we have been able to study the interaction of antigen-Ia-T cell in a way which has revealed some interesting results dealing with T cell activation and Ir gene defects.
KeywordsSpleen Cell Cell Hybrid Fine Specificity Cyanogen Bromide Costar Plate
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