T Cell Hybridomas Producing Antigen-Specific Factors Express Heavy-Chain Variable-Region Determinants
Amongst the approaches that have been attempted during the last years in order to immortalize functional T cells, the somatic cell hybridization was remarkably successful (1–5). Although not as abundant as continuous lines (6) nor stable as the viral transformed T cell lymphomas (7), the functional T cell hybridomas provide an adequate source for: a. somatic cell genetic studies, b. biochemical and molecular analyses of the T cell antigen recognizing unit, and c. functional analysis and characterization of soluble T cell factors that can replace the immunoregulatory activity mediated by the T cells.
KeywordsHybrid Cell Hybrid Clone Suppressor Factor Specific Helper Heavy Chain Variable Region
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