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T Cell Hybridomas Producing Antigen-Specific Factors Express Heavy-Chain Variable-Region Determinants

  • Z. Eshhar
  • T. Waks
  • H. Zinger
  • E. Mozes
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)

Abstract

Amongst the approaches that have been attempted during the last years in order to immortalize functional T cells, the somatic cell hybridization was remarkably successful (1–5). Although not as abundant as continuous lines (6) nor stable as the viral transformed T cell lymphomas (7), the functional T cell hybridomas provide an adequate source for: a. somatic cell genetic studies, b. biochemical and molecular analyses of the T cell antigen recognizing unit, and c. functional analysis and characterization of soluble T cell factors that can replace the immunoregulatory activity mediated by the T cells.

Keywords

Hybrid Cell Hybrid Clone Suppressor Factor Specific Helper Heavy Chain Variable Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Z. Eshhar
  • T. Waks
  • H. Zinger
  • E. Mozes

There are no affiliations available

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