Lectin-Dependent Cytolytic and Cytolymic T Helper Clones and Hybridomas

  • K. Fischer Lindahl
  • A. A. Nordin
  • M. H. Schreier
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 100)


Any cytotoxic T lymphocyte (CTL) will kill P815 or EL4 target cells on addition of a lectin such as phytohemagglutinin (PHA) or concanavalin A (Con A) (1,2), and lectin-dependent killing has been considered a prerogative of CTL (3). However, lectin-dependent killers could be found under conditions where no specific CTL were induced (4–6), and nearly every T cell clone stimulated by Con A and T cell growth factor (TCGF) caused 51Cr-release in the presence of PHA (7). It therefore seemed possible that any T cell can become a lectin-dependent killer. To find out how common this activity might be, we tested a set of antigen-specific, I-A-restricted T helper cell lines, clones and hybridomas (8–10).


Effector Cell Spleen Cell Helper Cell Spontaneous Release P81S Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • K. Fischer Lindahl
  • A. A. Nordin
  • M. H. Schreier

There are no affiliations available

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