Allergy to Radiographic Contrast Media: Accumulated Evidence for Antibody-mediated Human Toxicity and a New Animal Model

  • R. C. Brasch
  • J. Kay
  • S. Mark
  • D. Nitecki


The wide spectrum of radiographic contrast media (RCM) reactivity includes reactions which are also seen to occur with other drugs and are known to be mediated by antibody-antigen interaction. It is specifically the idiosyncratic, non-dose-dependent RCM reactions which are similar to the Type I allergic reactions that have been long-studied in man and animals. These reactions include sneezing, angioedema, urticaria, and more dread responses such as bronchospasm, laryngeal edema, cardiovascular collapse, and death.


Keyhole Limpet Hemocyanin Laryngeal Edema Fatal Reaction Adverse Reac Radiographic Contrast Medium 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • R. C. Brasch
  • J. Kay
  • S. Mark
  • D. Nitecki

There are no affiliations available

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