Abstract
The wide spectrum of radiographic contrast media (RCM) reactivity includes reactions which are also seen to occur with other drugs and are known to be mediated by antibody-antigen interaction. It is specifically the idiosyncratic, non-dose-dependent RCM reactions which are similar to the Type I allergic reactions that have been long-studied in man and animals. These reactions include sneezing, angioedema, urticaria, and more dread responses such as bronchospasm, laryngeal edema, cardiovascular collapse, and death.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wakkers-Garritsen BG, Houwerziji J, Nater JP, Wakkers PJM (1976) IgE-mediated adverse reactivity to a radiographic contrast medium — case report. Ann Allergy 36:122–126
Kleinknecht D, Deloux J, Homberg JC (1974) Acute renal failure after intravenous urography: detection of antibodies against contrast media. Clin Nephrol 2:116–119
Harboe M, Foiling I, Haugen OA, Bauer K (1976) Sudden death caused by interaction between a macroglobulin and a divalent drug. Lancet 2:285–288
Brasch RC, Caldwell JL (1976) The allergic theory of radiocontrast agent toxicity: demonstration of antibody activity in sera of patients suffering major radiocontrast agent reactions. Invest Radiol 2:347–356
Brasch RC, Caldwell JL, Fudenberg HH (1976) Antibodies to radiographic contrast agents. Induction and characterization of rabbit antibody. Invest Radiol 2:1–9
Siegle RL, Lieberman P, Jennings BR, Rice MC (1980) Iodinated contrast material: studies relating to complement activation, atopy, cellular association, and antigenicity. Invest Radiol 15:513–517
Mossmann H, Meyer-Delius M, Vortisch U, Botho K, Hammer DK (1974) Experimental studies on the bridging hypothesis of anaphylaxis. J Exp Med 140:1468–1481
Fudenberg HH, Stites DP, Caldwell JL, Wells JV (1980) Basic and clinical immunology, 3rd edn. Lange Medical, Los Altos, CA p 193
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Brasch, R.C., Kay, J., Mark, S., Nitecki, D. (1982). Allergy to Radiographic Contrast Media: Accumulated Evidence for Antibody-mediated Human Toxicity and a New Animal Model. In: Amiel, M. (eds) Contrast Media in Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68584-2_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-68584-2_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11534-2
Online ISBN: 978-3-642-68584-2
eBook Packages: Springer Book Archive