Advertisement

Allergy to Radiographic Contrast Media: Accumulated Evidence for Antibody-mediated Human Toxicity and a New Animal Model

  • R. C. Brasch
  • J. Kay
  • S. Mark
  • D. Nitecki

Abstract

The wide spectrum of radiographic contrast media (RCM) reactivity includes reactions which are also seen to occur with other drugs and are known to be mediated by antibody-antigen interaction. It is specifically the idiosyncratic, non-dose-dependent RCM reactions which are similar to the Type I allergic reactions that have been long-studied in man and animals. These reactions include sneezing, angioedema, urticaria, and more dread responses such as bronchospasm, laryngeal edema, cardiovascular collapse, and death.

Keywords

Keyhole Limpet Hemocyanin Laryngeal Edema Fatal Reaction Adverse Reac Radiographic Contrast Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wakkers-Garritsen BG, Houwerziji J, Nater JP, Wakkers PJM (1976) IgE-mediated adverse reactivity to a radiographic contrast medium — case report. Ann Allergy 36:122–126PubMedGoogle Scholar
  2. 2.
    Kleinknecht D, Deloux J, Homberg JC (1974) Acute renal failure after intravenous urography: detection of antibodies against contrast media. Clin Nephrol 2:116–119PubMedGoogle Scholar
  3. 3.
    Harboe M, Foiling I, Haugen OA, Bauer K (1976) Sudden death caused by interaction between a macroglobulin and a divalent drug. Lancet 2:285–288PubMedCrossRefGoogle Scholar
  4. 4.
    Brasch RC, Caldwell JL (1976) The allergic theory of radiocontrast agent toxicity: demonstration of antibody activity in sera of patients suffering major radiocontrast agent reactions. Invest Radiol 2:347–356CrossRefGoogle Scholar
  5. 5.
    Brasch RC, Caldwell JL, Fudenberg HH (1976) Antibodies to radiographic contrast agents. Induction and characterization of rabbit antibody. Invest Radiol 2:1–9CrossRefGoogle Scholar
  6. 6.
    Siegle RL, Lieberman P, Jennings BR, Rice MC (1980) Iodinated contrast material: studies relating to complement activation, atopy, cellular association, and antigenicity. Invest Radiol 15:513–517Google Scholar
  7. 7.
    Mossmann H, Meyer-Delius M, Vortisch U, Botho K, Hammer DK (1974) Experimental studies on the bridging hypothesis of anaphylaxis. J Exp Med 140:1468–1481PubMedCrossRefGoogle Scholar
  8. 8.
    Fudenberg HH, Stites DP, Caldwell JL, Wells JV (1980) Basic and clinical immunology, 3rd edn. Lange Medical, Los Altos, CA p 193Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • R. C. Brasch
  • J. Kay
  • S. Mark
  • D. Nitecki

There are no affiliations available

Personalised recommendations