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Toxicology and Pharmacology of Aminoglycoside Antibiotics

  • Chapter
Aminoglycoside Antibiotics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 62))

Abstract

The major toxic effect of aminoglycosides is nephrotoxicity. In general, aminoglycosides are not metabolized in vivo, but are excreted by glomerular filtration. However, a portion can be reabsorbed via the proximal tubules and remain in the kidney, a process which may induce nephrotoxicity due to the damage of the tubules. Clinical pharmacologists have studied the detection of the early signs of nephrotoxicity and have searched for drugs which will alleviate nephrotoxicity.

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  1. T. Koeda
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  2. K. Umemura
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  3. M. Yokota
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Editors and Affiliations

  1. Institute of Microbial Chemistry, 14-23 Kamiosaki 3-Chome, Shinagawa-ku, Tokyo, Japan

    Hamao Umezawa

  2. Research Associate, Duke University Marine Laboratory, Pivers Island, 28516, Beaufort, NY, USA

    Irving R. Hooper

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Koeda, T., Umemura, K., Yokota, M. (1982). Toxicology and Pharmacology of Aminoglycoside Antibiotics. In: Umezawa, H., Hooper, I.R. (eds) Aminoglycoside Antibiotics. Handbook of Experimental Pharmacology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68579-8_7

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